Mettl1 methyltransferase 1, tRNA methylguanosine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl1provided by RGD
Official Full Name: methyltransferase 1, tRNA methylguanosineprovided by RGD
Primary source: RGD:1593036
See related: Ensembl:ENSRNOG00000047895 AllianceGenome:RGD:1593036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in RNA (guanine-N7)-methylation and tRNA methylation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 39.1), Kidney (RPKM 33.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (64750189..64754531)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (62864860..62869202)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70328470..70333045)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables internal mRNA (guanine-N7-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA (guanine-N7)-methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA (guanine-N7)-methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA (guanine-N7)-methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of tRNA (m7G46) methyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (guanine-N(7)-)-methyltransferase

Names: methyltransferase like 1

NP_001385862.1

EC 2.1.1.33

NP_001385863.1

EC 2.1.1.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398933.1 → NP_001385862.1 tRNA (guanine-N(7)-)-methyltransferase isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HQR6

Related

ENSRNOP00000064874.3, ENSRNOT00000075544.3

Conserved Domains (1) summary

pfam02390
Location:70 → 247

Methyltransf_4; Putative methyltransferase
NM_001398934.1 → NP_001385863.1 tRNA (guanine-N(7)-)-methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

Related

ENSRNOP00000093899.1, ENSRNOT00000117922.1

Conserved Domains (1) summary

pfam02390
Location:34 → 211

Methyltransf_4; Putative methyltransferase