Capns2 calpain, small subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Capns2provided by RGD
Official Full Name: calpain, small subunit 2provided by RGD
Primary source: RGD:1583620
See related: AllianceGenome:RGD:1583620
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Orthologous to human CAPNS2 (calpain small subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (30277324..30278266, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (14104334..14105276, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (15485258..15486200, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calpain small subunit 2

NP_001102850.1

EC 3.4.22.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109380.1 → NP_001102850.1 calpain small subunit 2

See identical proteins and their annotated locations for NP_001102850.1

Status: PROVISIONAL

Source sequence(s)

CH474037

UniProtKB/TrEMBL

A6KD57

Conserved Domains (2) summary

pfam13499
Location:154 → 209

EF-hand_7; EF-hand domain pair

cl08302
Location:123 → 168

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...