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Asb14 ankyrin repeat and SOCS box-containing 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680076, updated on 3-Apr-2024

Summary

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Official Symbol
Asb14provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 14provided by RGD
Primary source
RGD:1596812
See related
Ensembl:ENSRNOG00000013346 AllianceGenome:RGD:1596812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB14 (ankyrin repeat and SOCS box containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 151.7), Muscle (RPKM 148.3) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2102303..2131379)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2095567..2123259)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2537209..2556930)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 12 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene protein phosphatase 1, regulatory subunit 26, pseudogene 1 Neighboring gene host cell factor C1 regulator 1-like Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene HESX homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 14
Names
Ankyrin repeat and SOCS box-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170749.1 → NP_001164220.1  ankyrin repeat and SOCS box protein 14

    See identical proteins and their annotated locations for NP_001164220.1

    Status: VALIDATED

    Source sequence(s)
    AW919055, FM122942, JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P0C927
    UniProtKB/TrEMBL
    F1M704
    Related
    ENSRNOP00000017995.4, ENSRNOT00000017995.5
    Conserved Domains (4) summary
    cd00204
    Location:119 → 243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:536 → 592
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:161 → 252
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:189 → 220
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    2102303..2131379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275710.1 → XP_063131780.1  ankyrin repeat and SOCS box protein 14 isoform X1

  2. XM_063275711.1 → XP_063131781.1  ankyrin repeat and SOCS box protein 14 isoform X1

  3. XM_063275709.1 → XP_063131779.1  ankyrin repeat and SOCS box protein 14 isoform X1

  4. XM_063275712.1 → XP_063131782.1  ankyrin repeat and SOCS box protein 14 isoform X2

    UniProtKB/TrEMBL
    F1M704

  5. XM_063275713.1 → XP_063131783.1  ankyrin repeat and SOCS box protein 14 isoform X3

RNA

  1. XR_010058318.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C927.1 GenPept UniProtKB/Swiss-Prot:P0C927

Gene LinkOut

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