U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tasor transcription activation suppressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 680155, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Symbol
Tasorprovided by RGD
Full Name
transcription activation suppressorprovided by RGD
Primary source
RGD:1595469
See related
Ensembl:ENSRNOG00000014750 AllianceGenome:RGD:1595469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam208a
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including mesodermal to mesenchymal transition involved in gastrulation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and regulation of gene expression. Predicted to act upstream of or within in utero embryonic development and mitotic spindle assembly. Predicted to be active in heterochromatin and nucleoplasm. Orthologous to human TASOR (transcription activation suppressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 223.2), Thymus (RPKM 221.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tasor in Genome Data Viewer
Location:
16p16
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2612942..2669870)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2606807..2669902)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (3050506..3108168)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC102548056 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene uncharacterized LOC134482440 Neighboring gene coiled-coil domain containing 66 Neighboring gene ATP synthase c subunit lysine N-methyltransferase, pseudogene 1 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Liu N, et al. Nature, 2018 Jan 11. PMID 29211708, Free PMC Article
  2. GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Tchasovnikarova IA, et al. Science, 2015 Jun 26. PMID 26022416, Free PMC Article
  3. Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Tchasovnikarova IA, et al. Nat Genet, 2017 Jul. PMID 28581500, Free PMC Article
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo ISO
Inferred from Sequence Orthology
more info
  
involved_in mesodermal to mesenchymal transition involved in gastrulation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to heterochromatin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein TASOR
Names
family with sequence similarity 208, member A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427354.1 → NP_001414283.1  protein TASOR

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    2612942..2669870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003751541.5 → XP_003751589.1  protein TASOR isoform X3

    See identical proteins and their annotated locations for XP_003751589.1

    UniProtKB/TrEMBL
    A0A8I6AIB8, M0RAP6
    Related
    ENSRNOP00000088196.1
    Conserved Domains (1) summary
    pfam12509
    Location:162 → 323
    DUF3715; Protein of unknown function (DUF3715)

  2. XM_017600275.3 → XP_017455764.1  protein TASOR isoform X4

    UniProtKB/TrEMBL
    M0RAP6

  3. XM_063275715.1 → XP_063131785.1  protein TASOR isoform X5

    UniProtKB/TrEMBL
    A0A8I6GL28

  4. XM_006252675.3 → XP_006252737.1  protein TASOR isoform X1

    See identical proteins and their annotated locations for XP_006252737.1

    UniProtKB/TrEMBL
    M0RAP6
    Conserved Domains (1) summary
    pfam12509
    Location:162 → 323
    DUF3715; Protein of unknown function (DUF3715)

  5. XM_063275716.1 → XP_063131786.1  protein TASOR isoform X7

  6. XM_039095195.2 → XP_038951123.1  protein TASOR isoform X6

    UniProtKB/TrEMBL
    M0RAP6
    Conserved Domains (2) summary
    pfam04931
    Location:1271 → 1320
    DNA_pol_phi; DNA polymerase phi
    pfam12509
    Location:1 → 135
    DUF3715; Protein of unknown function (DUF3715)

  7. XM_017600274.3 → XP_017455763.2  protein TASOR isoform X2

    UniProtKB/TrEMBL
    M0RAP6
    Conserved Domains (2) summary
    pfam04931
    Location:1379 → 1428
    DNA_pol_phi; DNA polymerase phi
    pfam12509
    Location:90 → 243
    DUF3715; Protein of unknown function (DUF3715)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Tools
Miscellaneous