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Mark4 microtubule affinity regulating kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680407, updated on 13-Apr-2024

Summary

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Official Symbol
Mark4provided by RGD
Official Full Name
microtubule affinity regulating kinase 4provided by RGD
Primary source
RGD:1591792
See related
Ensembl:ENSRNOG00000017069 AllianceGenome:RGD:1591792
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase activity and tubulin binding activity. Predicted to be involved in several processes, including positive regulation of cilium assembly; positive regulation of protein localization to centrosome; and regulation of centrosome cycle. Predicted to be located in several cellular components, including dendrite; microtubule cytoskeleton; and midbody. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm. Orthologous to human MARK4 (microtubule affinity regulating kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 46.2), Testes (RPKM 34.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mark4 in Genome Data Viewer
Location:
1q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88203352..88239858, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79075353..79108882, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80335517..80367366, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene kinesin light chain 3 Neighboring gene creatine kinase, M-type Neighboring gene exocyst complex component 3-like 2 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Yu W, et al. Hum Mol Genet, 2012 Mar 15. PMID 22156579, Free PMC Article
  2. MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons. Tang EI, et al. Endocrinology, 2022 Oct 11. PMID 35971301, Free PMC Article
  3. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics. Rovina D, et al. Eur J Cell Biol, 2014 Aug-Sep. PMID 25123532
  4. Microtubule affinity-regulating kinase 4 (MARK4) is a component of the ectoplasmic specialization in the rat testis. Tang EI, et al. Spermatogenesis, 2012 Apr 1. PMID 22670221, Free PMC Article
  5. Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4. Schneider A, et al. J Neurochem, 2004 Mar. PMID 15009667

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
    Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
  2. MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
    Title: MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
  3. High MARK4 is associated with Alzheimer's disease.
    Title: A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal anchor activity ISO
Inferred from Sequence Orthology
more info
  
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-tubulin complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MAP/microtubule affinity-regulating kinase 4
NP_001178000.1
XP_006228534.1
XP_063129714.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191071.1 → NP_001178000.1  MAP/microtubule affinity-regulating kinase 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J8N3, D4A6T9
    Related
    ENSRNOP00000023392.2, ENSRNOT00000023392.6
    Conserved Domains (4) summary
    cd12197
    Location:654 → 752
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:59 → 310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328 → 370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58 → 310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    88203352..88239858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228472.5 → XP_006228534.1  MAP/microtubule affinity-regulating kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JTD8, A0A8I6A623
    Related
    ENSRNOP00000086560.1
    Conserved Domains (3) summary
    smart00220
    Location:59 → 310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328 → 370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58 → 310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  2. XM_063273644.1 → XP_063129714.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

    UniProtKB/TrEMBL
    D4A6T9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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