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Rsu1 Ras suppressor protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680419, updated on 5-Mar-2024

Summary

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Official Symbol
Rsu1provided by RGD
Official Full Name
Ras suppressor protein 1provided by RGD
Primary source
RGD:1591781
See related
Ensembl:ENSRNOG00000017595 AllianceGenome:RGD:1591781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in positive regulation of GTPase activity; positive regulation of cell-substrate adhesion; and signal transduction. Predicted to act upstream of or within Ras protein signal transduction and positive regulation of neural precursor cell proliferation. Predicted to be located in focal adhesion. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 185.8), Heart (RPKM 143.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81037848..81286127, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76128774..76377515, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80388477..80577338, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348618 Neighboring gene phosphotriesterase related Neighboring gene uncharacterized LOC134482609 Neighboring gene complement C1q like 3 Neighboring gene uncharacterized LOC134482610 Neighboring gene cubilin Neighboring gene uncharacterized LOC102550536 Neighboring gene tRNA aspartic acid methyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Cutler ML, et al. Mol Cell Biol, 1992 Sep. PMID 1508180, Free PMC Article
  2. The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading. Ito S, et al. Mol Biol Cell, 2010 Dec. PMID 20926685, Free PMC Article
  3. Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. Porcheri C, et al. J Neurosci, 2014 Apr 9. PMID 24719101, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras suppressor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109404.1 → NP_001102874.1  ras suppressor protein 1

    See identical proteins and their annotated locations for NP_001102874.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473990
    UniProtKB/TrEMBL
    A0A8I5ZQM5, A6JM38, D4A8F2
    Related
    ENSRNOP00000054637.5, ENSRNOT00000057827.5
    Conserved Domains (2) summary
    COG4886
    Location:38 → 202
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    81037848..81286127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276734.1 → XP_063132804.1  ras suppressor protein 1 isoform X2

  2. XM_063276735.1 → XP_063132805.1  ras suppressor protein 1 isoform X2

  3. XM_039096064.2 → XP_038951992.1  ras suppressor protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZQM5
    Conserved Domains (2) summary
    COG4886
    Location:38 → 202
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_039096062.2 → XP_038951990.1  ras suppressor protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQM5, A6JM38, D4A8F2
    Conserved Domains (2) summary
    COG4886
    Location:38 → 202
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_039096065.2 → XP_038951993.1  ras suppressor protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQM5
    Conserved Domains (2) summary
    COG4886
    Location:38 → 202
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_039096066.2 → XP_038951994.1  ras suppressor protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZQM5
    Conserved Domains (2) summary
    COG4886
    Location:38 → 202
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_005495332.2 RNA Sequence

  2. XR_010058931.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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