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Ckap2l cytoskeleton associated protein 2-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 680515, updated on 25-May-2024

Summary

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Official Symbol
Ckap2lprovided by RGD
Official Full Name
cytoskeleton associated protein 2-likeprovided by RGD
Primary source
RGD:1590645
See related
Ensembl:ENSRNOG00000026143 AllianceGenome:RGD:1590645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be active in centrosome; cytosol; and mitotic spindle. Human ortholog(s) of this gene implicated in Filippi syndrome. Orthologous to human CKAP2L (cytoskeleton associated protein 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 86.9), Spleen (RPKM 65.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ckap2l in Genome Data Viewer
Location:
3q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136950390..136977503, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (116497186..116524302, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121796221..121822352, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 20 member 1 Neighboring gene uncharacterized LOC102549265 Neighboring gene uncharacterized LOC120101660 Neighboring gene interleukin 1 alpha Neighboring gene interleukin 1 beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoskeleton-associated protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430741.1 → NP_001417670.1  cytoskeleton-associated protein 2-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001430742.1 → NP_001417671.1  cytoskeleton-associated protein 2-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    136950390..136977503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234995.5 → XP_006235057.1  cytoskeleton-associated protein 2-like isoform X2

    UniProtKB/TrEMBL
    A6HQ58
    Conserved Domains (2) summary
    pfam15297
    Location:425 → 732
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    pfam15744
    Location:40 → 165
    UPF0492; Uncharacterized protein family UPF0492

  2. XM_001057508.8 → XP_001057508.3  cytoskeleton-associated protein 2-like isoform X1

    UniProtKB/TrEMBL
    D3Z8Z9
    Related
    ENSRNOP00000034964.3
    Conserved Domains (2) summary
    pfam15297
    Location:425 → 733
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    pfam15744
    Location:40 → 165
    UPF0492; Uncharacterized protein family UPF0492
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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