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Glis3 GLIS family zinc finger 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680671, updated on 20-May-2024

Summary

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Symbol
Glis3provided by RGD
Full Name
GLIS family zinc finger 3provided by RGD
Primary source
RGD:1565505
See related
Ensembl:ENSRNOG00000014768 AllianceGenome:RGD:1565505
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565505
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 82.4), Uterus (RPKM 15.7) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Glis3 in Genome Data Viewer
Location:
1q52
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (235389567..235809416, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (225976029..226395849, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (246380816..246564385, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase D, pseudogene 2 Neighboring gene RNA, U6 small nuclear 613 Neighboring gene phosphatidylethanolamine-binding protein 1-like Neighboring gene uncharacterized LOC120098084 Neighboring gene uncharacterized LOC102546345 Neighboring gene RNA, U6 small nuclear 525

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons. Calderari S, et al. Genomics, 2018 Mar. PMID 28911974
  2. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Yang Y, et al. Nucleic Acids Res, 2009 May. PMID 19264802, Free PMC Article
  3. GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. Kim YS, et al. Nucleic Acids Res, 2003 Oct 1. PMID 14500813, Free PMC Article
  4. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. ZeRuth GT, et al. PLoS One, 2015. PMID 26147758, Free PMC Article
  5. CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA. Sakai-Kato K, et al. Biochim Biophys Acta, 2008 Jul-Aug. PMID 18298960

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated beta cell dysfunction.
    Title: Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated β cell dysfunction.
  2. GLIS3 controls the expression of genes involved in autophagy. Glis3 sequence polymorphisms in the diabetic GK rat alter beta-cell function and modify neurogenesis in hippocampus neurons.
    Title: Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons.
  3. It may play a role in a number of physiological processes controlled by Glis3.
    Title: HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GLIS family zinc finger 3; zinc finger protein GLIS3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    235389567..235809416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101395.2 → XP_038957323.1  zinc finger protein GLIS3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFZ7
    Related
    ENSRNOP00000093536.1
    Conserved Domains (3) summary
    COG5048
    Location:539 → 839
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:558 → 652
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:569 → 591
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_039101397.2 → XP_038957325.1  zinc finger protein GLIS3 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:326 → 426
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_063281030.1 → XP_063137100.1  zinc finger protein GLIS3 isoform X2

  4. XM_039101396.2 → XP_038957324.1  zinc finger protein GLIS3 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:326 → 426
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_005499631.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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