Bmp8a bone morphogenetic protein 8a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmp8aprovided by RGD
Official Full Name: bone morphogenetic protein 8aprovided by RGD
Primary source: RGD:1585858
See related: Ensembl:ENSRNOG00000030155 AllianceGenome:RGD:1585858
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in several processes, including diet induced thermogenesis; energy homeostasis; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within germ cell development and spermatogenesis. Predicted to be active in extracellular space. Orthologous to several human genes including BMP8A (bone morphogenetic protein 8a). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 3.2), Lung (RPKM 2.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140874942..140902881, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135589839..135617785, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (141007462..141033511, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.
Title: Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:496645 (e-PCR)
- UniSTS:496645

Bmp8a (e-PCR), detects polymorphism
- UniSTS:496645

BE115320 (e-PCR)
- UniSTS:248137

NoName (e-PCR)
- UniSTS:225206

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109432.1 → NP_001102902.1 bone morphogenetic protein 8A precursor

See identical proteins and their annotated locations for NP_001102902.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6IS27, D3ZTI5

Related

ENSRNOP00000049643.2, ENSRNOT00000045922.3

Conserved Domains (2) summary

pfam00019
Location:298 → 398

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:32 → 248

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

140874942..140902881 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110766.2 → XP_038966694.1 bone morphogenetic protein 8A isoform X1

Conserved Domains (2) summary

cl40434
Location:120 → 224

TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily

cl02928
Location:46 → 73

TGFb_propeptide; TGF-beta propeptide