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Qsox2 quiescin sulfhydryl oxidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681023, updated on 11-Apr-2024

Summary

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Symbol
Qsox2provided by RGD
Full Name
quiescin sulfhydryl oxidase 2provided by RGD
Primary source
RGD:1584720
See related
Ensembl:ENSRNOG00000018574 AllianceGenome:RGD:1584720
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable flavin-linked sulfhydryl oxidase activity and protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in extracellular space. Predicted to be integral component of Golgi membrane. Orthologous to human QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 77.9), Adrenal (RPKM 56.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Qsox2 in Genome Data Viewer
Location:
3p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29433091..29462739, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9034994..9064649, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3662324..3691972, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 250 Neighboring gene LIM homeobox 3 Neighboring gene uncharacterized LOC120101510 Neighboring gene coiled-coil domain containing 187 Neighboring gene G-protein signaling modulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sulfhydryl oxidase 2
Names
quiescin Q6 sulfhydryl oxidase 2
NP_001102904.1
XP_017447529.1
XP_038961783.1
XP_063140615.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109434.1 → NP_001102904.1  sulfhydryl oxidase 2

    See identical proteins and their annotated locations for NP_001102904.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/TrEMBL
    A6JTC7, D3ZP13
    Related
    ENSRNOP00000058448.2, ENSRNOT00000061735.3
    Conserved Domains (2) summary
    cd02992
    Location:71 → 184
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:441 → 538
    Evr1_Alr; Erv1 / Alr family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    29433091..29462739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592040.3 → XP_017447529.1  sulfhydryl oxidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARL2
    Related
    ENSRNOP00000096929.1

  2. XM_039105855.2 → XP_038961783.1  sulfhydryl oxidase 2 isoform X2

    Conserved Domains (3) summary
    pfam04777
    Location:260 → 345
    Evr1_Alr; Erv1 / Alr family
    pfam18108
    Location:14 → 121
    QSOX_Trx1; QSOX Trx-like domain
    pfam18371
    Location:147 → 250
    FAD_SOX; Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase

  3. XM_063284545.1 → XP_063140615.1  sulfhydryl oxidase 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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