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Vps25 vacuolar protein sorting 25 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 681059, updated on 13-Apr-2024

Summary

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Official Symbol
Vps25provided by RGD
Official Full Name
vacuolar protein sorting 25 homologprovided by RGD
Primary source
RGD:1584685
See related
Ensembl:ENSRNOG00000020441 AllianceGenome:RGD:1584685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein N-terminus binding activity; protein homodimerization activity; and structural molecule activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol; endosome membrane; and nucleus. Predicted to be part of ESCRT II complex. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 255.1), Adrenal (RPKM 190.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86696330..86701871)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86196062..86201606)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89174684..89180165)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095184 Neighboring gene receptor activity modifying protein 2 Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene ATP synthase membrane subunit K, pseudogene 2 Neighboring gene cytochrome C oxidase assembly factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. Kamura T, et al. J Biol Chem, 2001 May 11. PMID 11278625
  2. Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. Bowers K, et al. J Biol Chem, 2006 Feb 24. PMID 16371348
  3. RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. Wang T, et al. Biochem Biophys Res Commun, 2006 Nov 17. PMID 17010938
  4. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. Langelier C, et al. J Virol, 2006 Oct. PMID 16973552, Free PMC Article
  5. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Martin-Serrano J, et al. Proc Natl Acad Sci U S A, 2003 Oct 14. PMID 14519844, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT II complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT II complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vacuolar protein-sorting-associated protein 25
Names
ELL-associated protein of 20 kDa
ESCRT-II complex subunit VPS25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173451.1 → NP_001166922.1  vacuolar protein-sorting-associated protein 25

    See identical proteins and their annotated locations for NP_001166922.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P0C0A1
    UniProtKB/TrEMBL
    A0A096MJ61
    Related
    ENSRNOP00000068003.2, ENSRNOT00000075953.2
    Conserved Domains (1) summary
    pfam05871
    Location:10 → 139
    ESCRT-II; ESCRT-II complex subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86696330..86701871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086821.2 → XP_038942749.1  vacuolar protein-sorting-associated protein 25 isoform X1

    UniProtKB/TrEMBL
    A6HJ97
    Conserved Domains (1) summary
    pfam05871
    Location:29 → 158
    ESCRT-II; ESCRT-II complex subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C0A1.1 GenPept UniProtKB/Swiss-Prot:P0C0A1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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