Cenph centromere protein H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenphprovided by RGD
Official Full Name: centromere protein Hprovided by RGD
Primary source: RGD:1583506
See related: Ensembl:ENSRNOG00000018615 AllianceGenome:RGD:1583506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable kinetochore binding activity. Predicted to be involved in chromosome segregation and mitotic spindle organization. Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be active in kinetochore and nucleus. Orthologous to human CENPH (centromere protein H). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 39.0), Spleen (RPKM 32.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (33630738..33644258, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (31896675..31910179, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (30766637..30780123, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinetochore binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinetochore binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in kinetochore assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centromere protein H

Names: centromere autoantigen H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399529.1 → NP_001386458.1 centromere protein H isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

F1M389

Related

ENSRNOP00000025129.7, ENSRNOT00000025129.9

Conserved Domains (2) summary

PHA02562
Location:25 → 200

46; endonuclease subunit; Provisional

pfam05837
Location:122 → 231

CENP-H; Centromere protein H (CENP-H)
NM_001399532.1 → NP_001386461.1 centromere protein H isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002