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Cgnl1 cingulin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 68178, updated on 30-Apr-2024

Summary

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Official Symbol
Cgnl1provided by MGI
Official Full Name
cingulin-like 1provided by MGI
Primary source
MGI:MGI:1915428
See related
Ensembl:ENSMUSG00000032232 AllianceGenome:MGI:1915428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jacop; 4933421H10Rik; 9930020M10Rik
Summary
This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Broad expression in kidney adult (RPKM 30.5), placenta adult (RPKM 10.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Cgnl1 in Genome Data Viewer
Location:
9 D; 9 39.85 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71533789..71716582, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71626507..71809300, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71454614-71454767 Neighboring gene STARR-seq mESC enhancer starr_24576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71471793-71471976 Neighboring gene STARR-seq mESC enhancer starr_24577 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 pseudogene Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene STARR-positive B cell enhancer mm9_chr9:71493898-71494198 Neighboring gene predicted gene, 51713 Neighboring gene STARR-seq mESC enhancer starr_24580 Neighboring gene STARR-seq mESC enhancer starr_24581 Neighboring gene STARR-seq mESC enhancer starr_24582 Neighboring gene STARR-seq mESC enhancer starr_24583 Neighboring gene transcription factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E2904 Neighboring gene splicing factor, arginine/serine-rich 7 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:71799166-71799467 Neighboring gene STARR-positive B cell enhancer mm9_chr9:71823828-71824128 Neighboring gene ribosomal protein L15, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex. Citi S, et al. Ann N Y Acad Sci, 2012 Jun. PMID 22671598
  2. Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization. Flinois A, et al. J Cell Sci, 2024 Mar 1. PMID 37013686, Free PMC Article
  3. Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis. Chrifi I, et al. Cardiovasc Res, 2017 Dec 1. PMID 29016873, Free PMC Article
  4. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. Ohnishi H, et al. J Biol Chem, 2004 Oct 29. PMID 15292197
  5. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
    Title: Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
  2. demonstrate a functional relevance for cingulin-like 1 as a defining factor in new vessel formation both in vitro and in vivo
    Title: Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis.
  3. JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons.
    Title: JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cingulin-like protein 1
Names
junction-associated coiled-coil protein
paracingulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304362.2 → NP_001291291.1  cingulin-like protein 1

    See identical proteins and their annotated locations for NP_001291291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093483, AC107662
    Consensus CDS
    CCDS23328.1
    UniProtKB/Swiss-Prot
    B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3
    UniProtKB/TrEMBL
    B2RY19
    Related
    ENSMUSP00000112479.2, ENSMUST00000122065.2
    Conserved Domains (1) summary
    pfam01576
    Location:611 → 1253
    Myosin_tail_1; Myosin tail

  2. NM_001407857.1 → NP_001394786.1  cingulin-like protein 1

    Status: REVIEWED

    Source sequence(s)
    AC107662
    UniProtKB/Swiss-Prot
    B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3

  3. NM_026599.6 → NP_080875.3  cingulin-like protein 1

    See identical proteins and their annotated locations for NP_080875.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093483, AC107662
    Consensus CDS
    CCDS23328.1
    UniProtKB/Swiss-Prot
    B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3
    UniProtKB/TrEMBL
    B2RY19
    Related
    ENSMUSP00000072672.3, ENSMUST00000072899.9
    Conserved Domains (1) summary
    pfam01576
    Location:611 → 1253
    Myosin_tail_1; Myosin tail

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    71533789..71716582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511395.1 → XP_006511458.1  cingulin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511458.1

    UniProtKB/Swiss-Prot
    B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3
    UniProtKB/TrEMBL
    B2RY19
    Conserved Domains (1) summary
    pfam01576
    Location:611 → 1253
    Myosin_tail_1; Myosin tail
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AW69.3 GenPept UniProtKB/Swiss-Prot:Q6AW69

Gene LinkOut

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