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G6pc2 glucose-6-phosphatase catalytic subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681817, updated on 5-Mar-2024

Summary

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Official Symbol
G6pc2provided by RGD
Official Full Name
glucose-6-phosphatase catalytic subunit 2provided by RGD
Primary source
RGD:69398
See related
AllianceGenome:RGD:69398
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Igrp; G6pc-rs
Summary
Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in glucose homeostasis and regulation of insulin secretion. Predicted to be located in endoplasmic reticulum. Orthologous to human G6PC2 (glucose-6-phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 3.0) See more
Orthologs
human mouse all
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Genomic context

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See G6pc2 in Genome Data Viewer
Location:
3q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74404976..74413391)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (53999821..54005539)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55464528..55467170)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Y box binding protein 1, pseudogene 9 Neighboring gene nitric oxide synthase trafficking Neighboring gene SPC25 component of NDC80 kinetochore complex Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene DNA mismatch repair protein Msh6-like Neighboring gene dehydrogenase/reductase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells. Wang D, et al. Endocrinology, 2006 Jan. PMID 16223860
  2. Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. Martin CC, et al. J Biol Chem, 2001 Jul 6. PMID 11297555
  3. Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). Petrolonis AJ, et al. J Biol Chem, 2004 Apr 2. PMID 14722102
  4. Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. Hu C, et al. PLoS One, 2010 Jul 23. PMID 20668700, Free PMC Article
  5. Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. Garver WS, et al. J Lipid Res, 2000 May. PMID 10787428

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glucose-6-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
LOW QUALITY PROTEIN: glucose-6-phosphatase 2
Names
glucose-6-phosphatase 2
glucose-6-phosphatase, catalytic, 2
glucose-6-phosphatase, catalytic, related sequence
islet-specific glucose-6-phosphatase catalytic subunit-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    74404976..74413391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592318.3 → XP_017447807.2  LOW QUALITY PROTEIN: glucose-6-phosphatase 2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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