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Tmx3 thioredoxin-related transmembrane protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 682967, updated on 13-Apr-2024

Summary

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Official Symbol
Tmx3provided by RGD
Official Full Name
thioredoxin-related transmembrane protein 3provided by RGD
Primary source
RGD:1592777
See related
Ensembl:ENSRNOG00000045740 AllianceGenome:RGD:1592777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-disulfide reductase activity. Predicted to be involved in peptidyl-cysteine oxidation. Predicted to be located in cell surface and endoplasmic reticulum membrane. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 172.7), Brain (RPKM 159.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmx3 in Genome Data Viewer
Location:
18q13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (86021137..86054025)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (83731777..83764719)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (87580227..87613481)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene docking protein 6 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein eL32-like Neighboring gene zinc finger protein 950 like 16 Neighboring gene ribosomal protein S2, pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. Haugstetter J, et al. J Biol Chem, 2005 Mar 4. PMID 15623505
  2. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Holbrook LM, et al. Br J Haematol, 2010 Feb. PMID 19995400
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase TMX3
NP_001387727.1
XP_038953304.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400798.1 → NP_001387727.1  protein disulfide-isomerase TMX3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6K5P3, M0R402
    Related
    ENSRNOP00000064077.3, ENSRNOT00000070984.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    86021137..86054025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097376.2 → XP_038953304.1  protein disulfide-isomerase TMX3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARW7
    Conserved Domains (2) summary
    TIGR01130
    Location:1 → 275
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:1 → 61
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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