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Snx3 sorting nexin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684097, updated on 2-May-2024

Summary

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Official Symbol
Snx3provided by RGD
Official Full Name
sorting nexin 3provided by RGD
Primary source
RGD:1595151
See related
Ensembl:ENSRNOG00000046705 AllianceGenome:RGD:1595151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phosphate binding activity; protein phosphatase binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; intralumenal vesicle formation; and negative regulation of transport. Predicted to act upstream of or within several processes, including hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Human ortholog(s) of this gene implicated in syndromic microphthalmia 8. Orthologous to human SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 355.3), Kidney (RPKM 352.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snx3 in Genome Data Viewer
Location:
20q13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (47574051..47607577)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45992446..46025361)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (47225382..47263390)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene forkhead box O3 Neighboring gene AFG1 like ATPase Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene nuclear receptor subfamily 2, group E, member 1 Neighboring gene osteoclastogenesis associated transmembrane protein 1 Neighboring gene uncharacterized LOC134483933

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Braun V, et al. Cell Microbiol, 2010 Sep 1. PMID 20482551
  2. SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells. Chua RY, et al. Immunology, 2013 May. PMID 23237080, Free PMC Article
  3. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Mizutani R, et al. Cell Signal, 2009 Nov. PMID 19576982
  4. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Xu Y, et al. Nat Cell Biol, 2001 Jul. PMID 11433298
  5. Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2. Dong H, et al. Acta Biochim Biophys Sin (Shanghai), 2007 Jul. PMID 17622474

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
  
enables retromer complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intralumenal vesicle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane invagination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein to membrane docking ISO
Inferred from Sequence Orthology
more info
  
involved_in protein to membrane docking ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transferrin transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early phagosome ISO
Inferred from Sequence Orthology
more info
  
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044283.1 → NP_001037748.1  sorting nexin-3

    See identical proteins and their annotated locations for NP_001037748.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107918
    UniProtKB/Swiss-Prot
    Q5U211
    UniProtKB/TrEMBL
    A6K6Y8
    Related
    ENSRNOP00000092005.1, ENSRNOT00000074532.4
    Conserved Domains (1) summary
    cd07293
    Location:28 → 150
    PX_SNX3; The phosphoinositide binding Phox Homology domain of Sorting Nexin 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    47574051..47607577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099063.2 → XP_038954991.1  sorting nexin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A603, B0BMY2
    Related
    ENSRNOP00000087527.1
    Conserved Domains (1) summary
    cl02563
    Location:28 → 129
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. XM_039099064.2 → XP_038954992.1  sorting nexin-3 isoform X2

    Conserved Domains (1) summary
    cl02563
    Location:28 → 86
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U211.1 GenPept UniProtKB/Swiss-Prot:Q5U211

Gene LinkOut

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