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Trim68 tripartite motif containing 68 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684189, updated on 13-Apr-2024

Summary

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Official Symbol
Trim68provided by RGD
Official Full Name
tripartite motif containing 68provided by RGD
Primary source
RGD:1593867
See related
Ensembl:ENSRNOG00000047229 AllianceGenome:RGD:1593867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including androgen receptor binding activity; enzyme binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; protein ubiquitination; and regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIM68 (tripartite motif containing 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 50.6), Adrenal (RPKM 43.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trim68 in Genome Data Viewer
Location:
1q32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166525981..166539407, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (157114044..157127494, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167835773..167849880, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily I member 2 Neighboring gene olfactory receptor family 52 subfamily I member 2 like, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily D member 1 Neighboring gene olfactory receptor family 51 subfamily E member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. Miyajima N, et al. Cancer Res, 2008 May 1. PMID 18451177
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM68
NP_001388433.1
XP_038957035.1
XP_038957038.1
XP_038957039.1
XP_038957040.1
XP_038957041.1
XP_063129891.1
XP_063129897.1
XP_063129899.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401504.1 → NP_001388433.1  E3 ubiquitin-protein ligase TRIM68

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A1B0GWT9
    Related
    ENSRNOP00000076018.2, ENSRNOT00000092838.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    166525981..166539407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101112.2 → XP_038957040.1  E3 ubiquitin-protein ligase TRIM68 isoform X3

    UniProtKB/TrEMBL
    A0A1B0GWP0
    Conserved Domains (3) summary
    TIGR00599
    Location:16 → 117
    rad18; DNA repair protein rad18
    cd13733
    Location:243 → 418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16610
    Location:13 → 61
    RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins

  2. XM_039101111.2 → XP_038957039.1  E3 ubiquitin-protein ligase TRIM68 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GWP0, M0R4M4
    Related
    ENSRNOP00000064311.3
    Conserved Domains (3) summary
    cd13733
    Location:272 → 447
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16610
    Location:13 → 61
    RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
    cl00034
    Location:96 → 138
    Bbox_SF; B-box-type zinc finger superfamily

  3. XM_039101113.2 → XP_038957041.1  E3 ubiquitin-protein ligase TRIM68 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A0C0
    Related
    ENSRNOP00000083617.1
    Conserved Domains (3) summary
    cd00162
    Location:16 → 60
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:96 → 138
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:13 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_039101107.2 → XP_038957035.1  E3 ubiquitin-protein ligase TRIM68 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWP0, A0A1B0GWT9
    Conserved Domains (3) summary
    cd13733
    Location:304 → 479
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16610
    Location:13 → 61
    RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
    cl00034
    Location:96 → 138
    Bbox_SF; B-box-type zinc finger superfamily

  5. XM_063273821.1 → XP_063129891.1  E3 ubiquitin-protein ligase TRIM68 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWT9

  6. XM_063273829.1 → XP_063129899.1  E3 ubiquitin-protein ligase TRIM68 isoform X5

  7. XM_063273827.1 → XP_063129897.1  E3 ubiquitin-protein ligase TRIM68 isoform X2

    UniProtKB/TrEMBL
    M0R4M4

  8. XM_039101110.2 → XP_038957038.1  E3 ubiquitin-protein ligase TRIM68 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWP0, A0A1B0GWT9
    Related
    ENSRNOP00000075968.2
    Conserved Domains (3) summary
    cd13733
    Location:304 → 479
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16610
    Location:13 → 61
    RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
    cl00034
    Location:96 → 138
    Bbox_SF; B-box-type zinc finger superfamily
Nucleotide Protein Strain
Heading Accession and Version

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