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Mpzl1 myelin protein zero-like 1 [ Mus musculus (house mouse) ]

Gene ID: 68481, updated on 12-May-2024

Summary

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Official Symbol
Mpzl1provided by MGI
Official Full Name
myelin protein zero-like 1provided by MGI
Primary source
MGI:MGI:1915731
See related
Ensembl:ENSMUSG00000026566 AllianceGenome:MGI:1915731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PZR; 1110007A10Rik
Summary
Acts upstream of or within positive regulation of cell migration. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human MPZL1 (myelin protein zero like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 77.0), limb E14.5 (RPKM 61.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Mpzl1 in Genome Data Viewer
Location:
1 H2.3; 1 72.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165419745..165462144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165592176..165634541, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 10 Neighboring gene predicted gene, 51751 Neighboring gene predicted gene, 51750 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167509733-167510033 Neighboring gene STARR-positive B cell enhancer ABC_E11103 Neighboring gene STARR-positive B cell enhancer ABC_E4372 Neighboring gene STARR-positive B cell enhancer ABC_E324 Neighboring gene STARR-positive B cell enhancer ABC_E1570 Neighboring gene nuclear encoded tRNA proline 2 (anticodon AGG) Neighboring gene nuclear encoded tRNA proline 2 (anticodon CGG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion. Fu Y, et al. Aging (Albany NY), 2023 Jun 6. PMID 37279992, Free PMC Article
  2. Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines. Yi JS, et al. JCI Insight, 2020 Aug 6. PMID 32584792, Free PMC Article
  3. Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots. Leiva AG, et al. J Invest Dermatol, 2014 Jul. PMID 24531688, Free PMC Article
  4. The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation. Roubelakis MG, et al. J Cell Biochem, 2007 Nov 1. PMID 17440960
  5. Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. Eminaga S, et al. J Biol Chem, 2008 May 30. PMID 18378677, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion.
    Title: PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion.
  2. Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.
    Title: Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.
  3. These data reveal a complex role for Mpzl3 in the control of skin development, hair growth, and adipose cell functions.
    Title: Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.
  4. Phosphorylation and localization of PZR in cultufred endothelial cells is reported.
    Title: Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells.
  5. SIRPalpha and PZR serve as scaffolds that facilitate plasma membrane recruitment and signaling of NS-associated SHP-2 mutants.
    Title: Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation.
  6. describe the function of the mPZR isoforms in vivo, particularly with respect to their roles in regulating SHP-2-dependent cell migration during development.
    Title: The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myelin protein zero-like protein 1
Names
protein zero-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001880.2 → NP_001001880.1  myelin protein zero-like protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001001880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BB871672, BC072563, CX210059
    Consensus CDS
    CCDS35758.1
    UniProtKB/TrEMBL
    A0A0A6YW22, A0A0R4J0V2
    Related
    ENSMUSP00000070343.8, ENSMUST00000068705.13
    Conserved Domains (2) summary
    cd05715
    Location:39 → 154
    Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
    smart00410
    Location:43 → 154
    IG_like; Immunoglobulin like

  2. NM_001083897.1 → NP_001077366.1  myelin protein zero-like protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001077366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK169385, BB871672, CX210059
    Consensus CDS
    CCDS35757.1
    UniProtKB/Swiss-Prot
    Q2VW02, Q3TEW6, Q6GQX5
    UniProtKB/TrEMBL
    A0A0A6YWA2
    Related
    ENSMUSP00000107062.3, ENSMUST00000111435.9
    Conserved Domains (2) summary
    cd00096
    Location:38 → 42
    Ig; Ig strand A [structural motif]
    cl11960
    Location:38 → 154
    Ig; Immunoglobulin domain

  3. NM_001347128.1 → NP_001334057.1  myelin protein zero-like protein 1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC102776
    Consensus CDS
    CCDS83623.1
    UniProtKB/TrEMBL
    A0A0A6YXW1
    Related
    ENSMUSP00000142164.2, ENSMUST00000194437.6
    Conserved Domains (1) summary
    cl11960
    Location:39 → 86
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165419745..165462144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934160.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TEW6.1 GenPept UniProtKB/Swiss-Prot:Q3TEW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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