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Baiap2l2 BAR/IMD domain containing adaptor protein 2 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685357, updated on 13-Apr-2024

Summary

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Official Symbol
Baiap2l2provided by RGD
Official Full Name
BAR/IMD domain containing adaptor protein 2 like 2provided by RGD
Primary source
RGD:1595091
See related
Ensembl:ENSRNOG00000012215 AllianceGenome:RGD:1595091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308786
Summary
Predicted to enable identical protein binding activity and phospholipid binding activity. Predicted to be involved in actin filament organization; membrane organization; and positive regulation of cytoskeleton organization. Predicted to be located in cell-cell contact zone and vesicle membrane. Predicted to be part of clathrin complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human BAIAP2L2 (BAR/IMD domain containing adaptor protein 2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 145.0) and Thymus (RPKM 7.3) See more
Orthologs
human mouse all
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Genomic context

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See Baiap2l2 in Genome Data Viewer
Location:
7q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112704798..112731691, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110824370..110850702, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120492366..120518803, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479937 Neighboring gene protein interacting with PRKCA 1 Neighboring gene solute carrier family 16 member 8 Neighboring gene phospholipase A2 group VI Neighboring gene MAF bZIP transcription factor F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Pykäläinen A, et al. Nat Struct Mol Biol, 2011 Jul 10. PMID 21743456, Free PMC Article
  2. Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Veltman DM, et al. Biochem J, 2011 May 15. PMID 21401524
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Names
BAI1-associated protein 2-like 2
rCG60233-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271220.1 → NP_001258149.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001258149.1

    Status: VALIDATED

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HSR1, D4A901
    Related
    ENSRNOP00000016362.6, ENSRNOT00000016362.6
    Conserved Domains (2) summary
    cd07644
    Location:6 → 220
    I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cd11914
    Location:327 → 385
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

  2. NM_001402152.1 → NP_001389081.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112704798..112731691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264259.1 → XP_063120329.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X4

  2. XM_039079895.2 → XP_038935823.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X2

    Conserved Domains (3) summary
    cd11914
    Location:319 → 377
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    PHA03247
    Location:229 → 542
    PHA03247; large tegument protein UL36; Provisional
    cl12013
    Location:85 → 212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_039079898.2 → XP_038935826.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X5

    Conserved Domains (2) summary
    cd11914
    Location:319 → 377
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cl12013
    Location:85 → 212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_039079894.2 → XP_038935822.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X1

    Conserved Domains (3) summary
    cd11914
    Location:319 → 377
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    PHA03247
    Location:229 → 549
    PHA03247; large tegument protein UL36; Provisional
    cl12013
    Location:85 → 212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_063264260.1 → XP_063120330.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X6

  6. XM_039079897.2 → XP_038935825.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

    Conserved Domains (2) summary
    cd11914
    Location:224 → 282
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cl12013
    Location:1 → 117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_005486728.2 RNA Sequence

  2. XR_010053042.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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