Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ecscrprovided by MGI
Official Full Name: endothelial cell surface expressed chemotaxis and apoptosis regulatorprovided by MGI
Primary source: MGI:MGI:1915795
See related: Ensembl:ENSMUSG00000073599 AllianceGenome:MGI:1915795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARIA; 1110006O17Rik
Summary: Acts upstream of or within negative regulation of angiogenesis. Located in cytosol and plasma membrane. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system gland; male reproductive gland or organ; and respiratory system. Orthologous to human ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 33.2), bladder adult (RPKM 20.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.22 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35846139..35855460, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35713086..35722413, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that ECSCR plays a critical function in regulating lipolysis in white adipose tissue.
Title: Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway.
two mouse ECSCR splicing variants/isoform precursors exist and are differentially expressed in a variety of tissue types and likely involved in modulation of vascular Endothelial cell migration.
Title: Structural and functional characterization of two alternative splicing variants of mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR).
These studies, revealed a previously undescribed mode of manipulating cardiac PI3K/Akt signaling by ARIA, thus identifying it as an attractive new target for the prevention of stress-induced myocardial dysfunction.
Title: Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.
Inactivation of Ecscr enhances insulin sensitivity and may represent a new therapeutic strategy for treating metabolic syndrome.
Title: Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.
ARIA was expressed in blood vessels during mouse embryogenesis, as well as in endothelial cells both in vitro and in vivo.
Title: Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of endothelial cell apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: endothelial cell-specific chemotaxis regulator

Names: apoptosis regulator through modulating IAP expression; endothelial cell-specific molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033141.2 → NP_001028313.1 endothelial cell-specific chemotaxis regulator isoform 3

See identical proteins and their annotated locations for NP_001028313.1

Status: VALIDATED

Source sequence(s)

AC132837

Consensus CDS

CCDS37763.1

UniProtKB/Swiss-Prot

C3RSF3, Q3TZW0

Related

ENSMUSP00000095223.4, ENSMUST00000097618.10

Conserved Domains (1) summary

pfam15820
Location:134 → 228

ECSCR; Endothelial cell-specific chemotaxis regulator
NM_001368651.1 → NP_001355580.1 endothelial cell-specific chemotaxis regulator isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC132837, CX567856

Consensus CDS

CCDS89219.1

UniProtKB/Swiss-Prot

C3RSF3, Q3TZW0

UniProtKB/TrEMBL

G3UVV5

Related

ENSMUSP00000118628.2, ENSMUST00000133064.8

Conserved Domains (1) summary

pfam15820
Location:139 → 233

ECSCR; Endothelial cell-specific chemotaxis regulator
NM_001368652.1 → NP_001355581.1 endothelial cell-specific chemotaxis regulator isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC132837

UniProtKB/TrEMBL

A0A494BAU9

Conserved Domains (1) summary

pfam15820
Location:139 → 200

ECSCR; Endothelial cell-specific chemotaxis regulator