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Gtf3c4 general transcription factor IIIC subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685539, updated on 5-Mar-2024

Summary

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Official Symbol
Gtf3c4provided by RGD
Official Full Name
general transcription factor IIIC subunit 4provided by RGD
Primary source
RGD:1592609
See related
Ensembl:ENSRNOG00000054725 AllianceGenome:RGD:1592609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone acetyltransferase activity. Predicted to be involved in histone acetylation and transcription initiation from RNA polymerase III promoter. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C4 (general transcription factor IIIC subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 55.7), Kidney (RPKM 54.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gtf3c4 in Genome Data Viewer
Location:
3p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32552773..32570705, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12154803..12172795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7404857..7422779, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 8 Neighboring gene RNA, U1 small nuclear 136 Neighboring gene DEAD-box helicase 31 Neighboring gene BarH-like homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385
  2. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase III general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase III promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor 3C polypeptide 4
Names
general transcription factor IIIC, polypeptide 4
NP_001102943.1
XP_006233933.1
XP_038961793.1
XP_063140630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109473.1 → NP_001102943.1  general transcription factor 3C polypeptide 4

    See identical proteins and their annotated locations for NP_001102943.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/TrEMBL
    A0A8I6AGY8, A0A8I6GGZ8, A6JTQ1
    Related
    ENSRNOP00000092120.1, ENSRNOT00000105740.1
    Conserved Domains (2) summary
    pfam12660
    Location:741 → 813
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
    pfam12657
    Location:61 → 250
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    32552773..32570705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233871.5 → XP_006233933.1  general transcription factor 3C polypeptide 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GGZ8, D3ZD80
    Related
    ENSRNOP00000069275.2
    Conserved Domains (1) summary
    pfam12657
    Location:61 → 250
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term

  2. XM_039105865.2 → XP_038961793.1  general transcription factor 3C polypeptide 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGY8, A0A8I6GGZ8, A6JTQ1
    Conserved Domains (2) summary
    pfam12660
    Location:741 → 813
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
    pfam12657
    Location:61 → 250
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term

  3. XM_063284560.1 → XP_063140630.1  general transcription factor 3C polypeptide 4 isoform X3

RNA

  1. XR_005501985.2 RNA Sequence

  2. XR_005501984.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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