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Macrod2 mono-ADP ribosylhydrolase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685695, updated on 3-Apr-2024

Summary

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Symbol
Macrod2provided by RGD
Full Name
mono-ADP ribosylhydrolase 2provided by RGD
Primary source
RGD:1591318
See related
Ensembl:ENSRNOG00000050784 AllianceGenome:RGD:1591318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AABR07054000.1
Summary
Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to act upstream of or within brain development and response to bacterium. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 22.9), Testes (RPKM 3.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
3q41
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (148173821..150191077)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (127720066..129737511)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (135729839..136422082)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5 Neighboring gene U6 spliceosomal RNA Neighboring gene SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase Neighboring gene uncharacterized LOC134486166 Neighboring gene fibronectin leucine rich transmembrane protein 3 Neighboring gene uncharacterized LOC134486164 Neighboring gene uncharacterized LOC134486163 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC134486165 Neighboring gene uncharacterized LOC102554505 Neighboring gene uncharacterized LOC120101717

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The C20orf133 gene is disrupted in a patient with Kabuki syndrome. Maas NM, et al. J Med Genet, 2007 Sep. PMID 17586838, Free PMC Article
  2. Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. Chen D, et al. J Biol Chem, 2011 Apr 15. PMID 21257746, Free PMC Article
  3. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius G, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474712, Free PMC Article
  4. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Rosenthal F, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474714
  5. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP-ribosylglutamate hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, acting on glycosyl bonds ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribose glycohydrolase MACROD2; mono-ADP ribosylhydrolase 2
Names
MACRO domain containing 2
O-acetyl-ADP-ribose deacetylase MACROD2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428715.1 → NP_001415644.1  mono-ADP ribosylhydrolase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZYG2

  2. NM_001428716.1 → NP_001415645.1  mono-ADP ribosylhydrolase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001428717.1 → NP_001415646.1  mono-ADP ribosylhydrolase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001428718.1 → NP_001415647.1  mono-ADP ribosylhydrolase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001428719.1 → NP_001415648.1  mono-ADP ribosylhydrolase 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  6. NM_001428720.1 → NP_001415649.1  mono-ADP ribosylhydrolase 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  7. NM_001428721.1 → NP_001415650.1  mono-ADP ribosylhydrolase 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  8. NM_001428722.1 → NP_001415651.1  mono-ADP ribosylhydrolase 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AUQ6

  9. NM_001428723.1 → NP_001415652.1  mono-ADP ribosylhydrolase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    148173821..150191077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106853.2 → XP_038962781.1  ADP-ribose glycohydrolase MACROD2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLS6
    Conserved Domains (2) summary
    COG5271
    Location:245 → 479
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  2. XM_039106857.2 → XP_038962785.1  ADP-ribose glycohydrolase MACROD2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZLS6
    Conserved Domains (2) summary
    COG4547
    Location:247 → 454
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  3. XM_039106858.2 → XP_038962786.1  ADP-ribose glycohydrolase MACROD2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZLS6
    Conserved Domains (2) summary
    COG4547
    Location:247 → 453
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  4. XM_039106855.2 → XP_038962783.1  ADP-ribose glycohydrolase MACROD2 isoform X3

    Conserved Domains (2) summary
    TIGR00927
    Location:254 → 464
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  5. XM_039106854.2 → XP_038962782.1  ADP-ribose glycohydrolase MACROD2 isoform X2

    Related
    ENSRNOP00000084670.1
    Conserved Domains (2) summary
    TIGR00927
    Location:280 → 479
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  6. XM_039106856.2 → XP_038962784.1  ADP-ribose glycohydrolase MACROD2 isoform X4

    Related
    ENSRNOP00000078851.1
    Conserved Domains (2) summary
    TIGR00927
    Location:280 → 463
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  7. XM_039106860.2 → XP_038962788.1  ADP-ribose glycohydrolase MACROD2 isoform X7

    Conserved Domains (1) summary
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  8. XM_063284990.1 → XP_063141060.1  ADP-ribose glycohydrolase MACROD2 isoform X9

  9. XM_063284992.1 → XP_063141062.1  ADP-ribose glycohydrolase MACROD2 isoform X10

  10. XM_063284993.1 → XP_063141063.1  ADP-ribose glycohydrolase MACROD2 isoform X11

  11. XM_063284995.1 → XP_063141065.1  ADP-ribose glycohydrolase MACROD2 isoform X13

  12. XM_063284994.1 → XP_063141064.1  ADP-ribose glycohydrolase MACROD2 isoform X12

    UniProtKB/TrEMBL
    A0A8I6AUQ6

  13. XM_039106861.2 → XP_038962789.1  ADP-ribose glycohydrolase MACROD2 isoform X8

RNA

  1. XR_010064912.1 RNA Sequence

  2. XR_010064913.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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