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Casq1 calsequestrin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 686019, updated on 4-Jan-2025

Summary

Official Symbol
Casq1provided by RGD
Official Full Name
calsequestrin 1provided by RGD
Primary source
RGD:1586677
See related
EnsemblRapid:ENSRNOG00000006930 AllianceGenome:RGD:1586677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium ion binding activity. Involved in regulation of sequestering of calcium ion; response to denervation involved in regulation of muscle adaptation; and skeletal muscle tissue development. Located in I band; T-tubule; and terminal cisterna lumen. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 14187.2) See more
Orthologs
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Genomic context

See Casq1 in Genome Data Viewer
Location:
13q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87203021..87212710, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84670648..84680339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90592676..90602365, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene DDB1 and CUL4 associated factor 8 Neighboring gene proliferation and apoptosis adaptor protein 15 Neighboring gene ATPase Na+/K+ transporting subunit alpha 4 Neighboring gene ATPase Na+/K+ transporting subunit alpha 2 Neighboring gene immunoglobulin superfamily, member 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding PubMed 
enables calcium ion binding  
enables identical protein binding  
enables identical protein binding  
Process Evidence Code Pubs
acts_upstream_of_or_within endoplasmic reticulum organization  
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in positive regulation of store-operated calcium channel activity  
involved_in positive regulation of store-operated calcium channel activity  
involved_in protein polymerization  
involved_in protein polymerization  
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
involved_in regulation of sequestering of calcium ion PubMed 
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  
acts_upstream_of_or_within regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  
involved_in regulation of store-operated calcium entry  
involved_in regulation of store-operated calcium entry  
involved_in response to denervation involved in regulation of muscle adaptation PubMed 
acts_upstream_of_or_within response to heat  
involved_in response to muscle inactivity PubMed 
involved_in sarcomere organization  
involved_in sarcomere organization  
involved_in skeletal muscle tissue development PubMed 
Component Evidence Code Pubs
located_in I band PubMed 
located_in T-tubule PubMed 
is_active_in Z disc  
located_in endoplasmic reticulum  
located_in mitochondrial matrix  
located_in mitochondrial matrix  
located_in myofibril PubMed 
located_in sarcolemma PubMed 
located_in sarcoplasmic reticulum PubMed 
located_in sarcoplasmic reticulum  
is_active_in sarcoplasmic reticulum lumen  
located_in sarcoplasmic reticulum lumen  
located_in sarcoplasmic reticulum lumen  
located_in sarcoplasmic reticulum membrane  
located_in terminal cisterna PubMed 
located_in terminal cisterna lumen PubMed 

General protein information

Preferred Names
calsequestrin-1
Names
Aspartactin
Laminin-binding protein
calsequestrin 1 (fast-twitch, skeletal muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159594.1NP_001153066.1  calsequestrin-1 precursor

    See identical proteins and their annotated locations for NP_001153066.1

    Status: VALIDATED

    Source sequence(s)
    BE109529, CA334109, CB699232, FM056035
    UniProtKB/Swiss-Prot
    P19633
    UniProtKB/TrEMBL
    A6JG37
    Related
    ENSRNOP00000009344.6, ENSRNOT00000009344.8
    Conserved Domains (4) summary
    cd03065
    Location:39158
    PDI_b_Calsequestrin_N; PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...
    cd03066
    Location:160261
    PDI_b_Calsequestrin_middle; PDIb family, Calsequestrin subfamily, Middle TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...
    cd03074
    Location:262381
    PDI_b'_Calsequestrin_C; Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient ...
    pfam01216
    Location:37386
    Calsequestrin; Calsequestrin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    87203021..87212710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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