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Ephb4 EPH receptor B4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 686310, updated on 30-Apr-2024

Summary

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Official Symbol
Ephb4provided by RGD
Official Full Name
EPH receptor B4provided by RGD
Primary source
RGD:1583193
See related
Ensembl:ENSRNOG00000045952 AllianceGenome:RGD:1583193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including circulatory system development; ephrin receptor signaling pathway; and protein autophosphorylation. Predicted to act upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 196.6), Kidney (RPKM 173.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24963174..24988473, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19326411..19351667, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22393338..22418332, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene erythropoietin Neighboring gene zonadhesin Neighboring gene uncharacterized LOC134481172 Neighboring gene uncharacterized LOC103691283 Neighboring gene solute carrier family 12, member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Extracellular signal-regulated kinase inhibition prevents venous adaptive remodeling via regulation of Eph-B4. Guo Y, et al. Vascular, 2022 Feb. PMID 33706642
  2. EphB4 expression and biological significance in prostate cancer. Xia G, et al. Cancer Res, 2005 Jun 1. PMID 15930280
  3. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. Bennett BD, et al. J Biol Chem, 1994 May 13. PMID 8188704
  4. Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer. Ni Q, et al. Oncol Lett, 2020 Jan. PMID 31885720, Free PMC Article
  5. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy. Rivera JC, et al. Invest Ophthalmol Vis Sci, 2015 Dec. PMID 26670826

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis.
    Title: Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis.
  2. Extracellular signal-regulated kinase inhibition prevents venous adaptive remodeling via regulation of Eph-B4.
    Title: Extracellular signal-regulated kinase inhibition prevents venous adaptive remodeling via regulation of Eph-B4.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within venous blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ephrin type-B receptor 4
NP_001414515.1
XP_003751205.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427586.1 → NP_001414515.1  ephrin type-B receptor 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J030

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24963174..24988473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003751157.6 → XP_003751205.1  ephrin type-B receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_003751205.1

    UniProtKB/TrEMBL
    A0A8I6GKB3, M0RDA4
    Related
    ENSRNOP00000067602.3
    Conserved Domains (7) summary
    cd05065
    Location:619 → 887
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:916 → 982
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    smart00454
    Location:913 → 980
    SAM; Sterile alpha motif
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:443 → 535
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:624 → 883
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:571 → 619
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
Nucleotide Protein Strain
Heading Accession and Version

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