Trip6 thyroid hormone receptor interactor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trip6provided by RGD
Official Full Name: thyroid hormone receptor interactor 6provided by RGD
Primary source: RGD:1583180
See related: Ensembl:ENSRNOG00000048580 AllianceGenome:RGD:1583180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable interleukin-1 receptor binding activity and kinase binding activity. Predicted to be involved in positive regulation of NIK/NF-kappaB signaling; positive regulation of cell migration; and signal transduction. Predicted to act upstream of or within chordate embryonic development. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and nucleus. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human TRIP6 (thyroid hormone receptor interactor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 113.3), Lung (RPKM 96.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25022959..25027366)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19386212..19390619)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22451596..22456003)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-485-3p modulates neural stem cell differentiation and proliferation via regulating TRIP6 expression.
Title: MiR-485-3p modulates neural stem cell differentiation and proliferation via regulating TRIP6 expression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chordate embryonic development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thyroid receptor-interacting protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127570.1 → NP_001121042.1 thyroid receptor-interacting protein 6

See identical proteins and their annotated locations for NP_001121042.1

Status: PROVISIONAL

Source sequence(s)

BC161996

UniProtKB/TrEMBL

A0A096MJX8, A0A8I6AS72, B1WC42

Related

ENSRNOP00000094729.1, ENSRNOT00000077058.2

Conserved Domains (4) summary

cd09350
Location:283 → 336

LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

cd09357
Location:403 → 465

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

PHA03247
Location:3 → 256

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:343 → 402

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers