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Iqsec1 IQ motif and Sec7 domain ArfGEF 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 686590, updated on 13-Apr-2024

Summary

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Symbol
Iqsec1provided by RGD
Full Name
IQ motif and Sec7 domain ArfGEF 1provided by RGD
Primary source
RGD:1596313
See related
Ensembl:ENSRNOG00000060350 AllianceGenome:RGD:1596313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in nucleolus. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 143.5), Brain (RPKM 141.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iqsec1 in Genome Data Viewer
Location:
4q34
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124725917..125045351, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (123168719..123488300, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (123400717..123454656)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene uncharacterized LOC134486815 Neighboring gene solute carrier family 41, member 3 Neighboring gene uncharacterized LOC134486814 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nucleoporin 210 Neighboring gene uncharacterized LOC134486816 Neighboring gene histone deacetylase 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Down-regulation of GEP100 causes increase in E-cadherin levels and inhibits pancreatic cancer cell invasion. Xie CG, et al. PLoS One, 2012. PMID 22662237, Free PMC Article
  2. Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina. Sakagami H, et al. J Comp Neurol, 2013 Mar 1. PMID 22886754
  3. Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma. Menju T, et al. PLoS One, 2011. PMID 21966491, Free PMC Article
  4. Epidermal growth factor receptor-GEP100-Arf6 axis affects the prognosis of lung adenocarcinoma. Oka S, et al. Oncology, 2014. PMID 24902879
  5. Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays. Dmitriev AA, et al. Epigenetics, 2012 May. PMID 22491060

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
    Title: Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of focal adhesion disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ARF protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IQ motif and SEC7 domain-containing protein 1
Names
IQ motif and Sec7 domain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408959.1 → NP_001395888.1  IQ motif and SEC7 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  2. NM_001408960.1 → NP_001395889.1  IQ motif and SEC7 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6G7L1
    Related
    ENSRNOP00000081156.1, ENSRNOT00000113793.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    124725917..125045351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108750.2 → XP_038964678.1  IQ motif and SEC7 domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    pfam01369
    Location:587 → 775
    Sec7; Sec7 domain
    pfam16453
    Location:807 → 942
    IQ_SEC7_PH; PH domain

  2. XM_039108749.2 → XP_038964677.1  IQ motif and SEC7 domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    pfam01369
    Location:597 → 785
    Sec7; Sec7 domain
    pfam16453
    Location:817 → 952
    IQ_SEC7_PH; PH domain

  3. XM_039108758.2 → XP_038964686.1  IQ motif and SEC7 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8L2R061
    Conserved Domains (2) summary
    pfam01369
    Location:612 → 800
    Sec7; Sec7 domain
    pfam16453
    Location:832 → 967
    IQ_SEC7_PH; PH domain

  4. XM_039108760.2 → XP_038964688.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8L2R061
    Related
    ENSRNOP00000069092.2
    Conserved Domains (2) summary
    pfam01369
    Location:612 → 800
    Sec7; Sec7 domain
    pfam16453
    Location:832 → 967
    IQ_SEC7_PH; PH domain

  5. XM_039108759.2 → XP_038964687.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

    UniProtKB/Swiss-Prot
    A0A0G2JUG7
    UniProtKB/TrEMBL
    A0A8I6ANF6
    Related
    ENSRNOP00000095381.1
    Conserved Domains (2) summary
    pfam01369
    Location:612 → 800
    Sec7; Sec7 domain
    pfam16453
    Location:832 → 967
    IQ_SEC7_PH; PH domain

  6. XM_039108748.2 → XP_038964676.1  IQ motif and SEC7 domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    pfam01369
    Location:612 → 800
    Sec7; Sec7 domain
    pfam16453
    Location:832 → 967
    IQ_SEC7_PH; PH domain

  7. XM_039108756.2 → XP_038964684.1  IQ motif and SEC7 domain-containing protein 1 isoform X7

    UniProtKB/Swiss-Prot
    A0A0G2JUG7
    Conserved Domains (2) summary
    pfam01369
    Location:521 → 709
    Sec7; Sec7 domain
    pfam16453
    Location:741 → 876
    IQ_SEC7_PH; PH domain

  8. XM_063286695.1 → XP_063142765.1  IQ motif and SEC7 domain-containing protein 1 isoform X14

  9. XM_039108754.2 → XP_038964682.1  IQ motif and SEC7 domain-containing protein 1 isoform X6

    UniProtKB/Swiss-Prot
    A0A0G2JUG7
    Conserved Domains (2) summary
    pfam01369
    Location:523 → 711
    Sec7; Sec7 domain
    pfam16453
    Location:743 → 878
    IQ_SEC7_PH; PH domain

  10. XM_039108753.2 → XP_038964681.1  IQ motif and SEC7 domain-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    A0A0G2JUG7
    Conserved Domains (2) summary
    pfam01369
    Location:526 → 714
    Sec7; Sec7 domain
    pfam16453
    Location:746 → 881
    IQ_SEC7_PH; PH domain

  11. XM_063286694.1 → XP_063142764.1  IQ motif and SEC7 domain-containing protein 1 isoform X13

  12. XM_039108762.2 → XP_038964690.1  IQ motif and SEC7 domain-containing protein 1 isoform X16

    UniProtKB/TrEMBL
    A6IB89
    Conserved Domains (3) summary
    PHA03307
    Location:89 → 306
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01369
    Location:401 → 589
    Sec7; Sec7 domain
    pfam16453
    Location:621 → 756
    IQ_SEC7_PH; PH domain

  13. XM_063286693.1 → XP_063142763.1  IQ motif and SEC7 domain-containing protein 1 isoform X11

  14. XM_063286696.1 → XP_063142766.1  IQ motif and SEC7 domain-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I6GBT6

  15. XM_006236890.5 → XP_006236952.1  IQ motif and SEC7 domain-containing protein 1 isoform X12

    UniProtKB/Swiss-Prot
    A0A0G2JUG7
    Related
    ENSRNOP00000081495.1
    Conserved Domains (3) summary
    PHA03307
    Location:210 → 427
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01369
    Location:522 → 710
    Sec7; Sec7 domain
    pfam16453
    Location:742 → 872
    IQ_SEC7_PH; PH domain

  16. XM_039108751.2 → XP_038964679.1  IQ motif and SEC7 domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5YC35
    Related
    ENSRNOP00000085130.1
    Conserved Domains (2) summary
    pfam01369
    Location:522 → 710
    Sec7; Sec7 domain
    pfam16453
    Location:742 → 877
    IQ_SEC7_PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0G2JUG7.1 GenPept UniProtKB/Swiss-Prot:A0A0G2JUG7

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