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Tbl2 transducin (beta)-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 686610, updated on 3-Apr-2024

Summary

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Official Symbol
Tbl2provided by RGD
Official Full Name
transducin (beta)-like 2provided by RGD
Primary source
RGD:1595038
See related
Ensembl:ENSRNOG00000046252 AllianceGenome:RGD:1595038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphoprotein binding activity; protein kinase binding activity; and translation initiation factor binding activity. Predicted to be involved in cellular response to glucose starvation; cellular response to hypoxia; and endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum. Orthologous to human TBL2 (transducin beta like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 96.0), Liver (RPKM 63.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbl2 in Genome Data Viewer
Location:
12q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27154150..27168446, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21517600..21531896, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24565843..24578855, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain, 1B Neighboring gene 5S ribosomal RNA Neighboring gene BAF chromatin remodeling complex subunit BCL7B Neighboring gene MLX interacting protein-like Neighboring gene VPS37D subunit of ESCRT-I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress. Tsukumo Y, et al. PLoS One, 2014. PMID 25393282, Free PMC Article
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transducin beta-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398915.1 → NP_001385844.1  transducin beta-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A096MJZ2, A6J0E6, M0RCS2
    Related
    ENSRNOP00000067401.3, ENSRNOT00000075138.3
    Conserved Domains (2) summary
    sd00039
    Location:89 → 132
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:78 → 394
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    27154150..27168446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090078.2 → XP_038946006.1  transducin beta-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J0E7
    Conserved Domains (2) summary
    sd00039
    Location:1 → 41
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1 → 303
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_063271658.1 → XP_063127728.1  transducin beta-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J0E7

  3. XM_039090079.2 → XP_038946007.1  transducin beta-like protein 2 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:68 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:20 → 233
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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