Pcca propionyl-CoA carboxylase subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pccaprovided by RGD
Official Full Name: propionyl-CoA carboxylase subunit alphaprovided by RGD
Primary source: RGD:3264
See related: Ensembl:ENSRNOG00000057042 AllianceGenome:RGD:3264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and propionyl-CoA carboxylase activity. Predicted to be involved in cellular amino acid catabolic process and fatty acid catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 172.1), Kidney (RPKM 153.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q25

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (106034586..106374908)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (99627955..99969555)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (108960509..109306879)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methylmalonyl-CoA mutase and PCCA show a much higher expression level in the entire CNS than in the liver, suggesting a different, but important function of this pathway during brain development.
Title: Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Got102 (e-PCR)
- UniSTS:113486

Pcca (e-PCR), detects polymorphism
- UniSTS:527476

D15Rat63 (e-PCR)
- UniSTS:118412

RH94721 (e-PCR)
- UniSTS:119968

RH144434 (e-PCR)
- UniSTS:233679

BE107713 (e-PCR)
- UniSTS:247019

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables propionyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA carboxylase activity	ISO Inferred from Sequence Orthology more info
enables propionyl-CoA carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables propionyl-CoA carboxylase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic complex	IEA Inferred from Electronic Annotation more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: propionyl-CoA carboxylase alpha chain, mitochondrial

Names: PCCase alpha subunit; PCCase subunit alpha; Propionyl Coenzyme A carboxylase alpha polypeptide; propanoyl-CoA:carbon dioxide ligase alpha subunit; propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA carboxylase, alpha polypeptide; propionyl-CoA carboxylase alpha subunit; propionyl-coenzyme A carboxylase, alpha polypeptide

NP_062203.2

EC 6.4.1.3

XP_038949592.1

EC 6.4.1.3

XP_063130717.1

EC 6.4.1.3

XP_063130718.1

EC 6.4.1.3

XP_063130719.1

EC 6.4.1.3

XP_063130720.1

EC 6.4.1.3

XP_063130721.1

EC 6.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019330.2 → NP_062203.2 propionyl-CoA carboxylase alpha chain, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6HUM3

Related

ENSRNOP00000087798.1, ENSRNOT00000096028.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

106034586..106374908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274647.1 → XP_063130717.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZVD4
XM_063274648.1 → XP_063130718.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2
XM_063274649.1 → XP_063130719.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A0G2K401
XM_063274650.1 → XP_063130720.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X4
XM_039093664.2 → XP_038949592.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8I5ZL37, A0A8I5ZWE0

Related

ENSRNOP00000082095.1

Conserved Domains (1) summary

cl39082
Location:58 → 667

PycA; Pyruvate carboxylase [Energy production and conversion]
XM_063274651.1 → XP_063130721.1 propionyl-CoA carboxylase alpha chain, mitochondrial isoform X6