Rgmb repulsive guidance molecule family member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgmbprovided by MGI
Official Full Name: repulsive guidance molecule family member Bprovided by MGI
Primary source: MGI:MGI:1916049
See related: Ensembl:ENSMUSG00000048027 AllianceGenome:MGI:1916049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DRAGON; 1110059F19Rik
Summary: Enables identical protein binding activity. Involved in positive regulation of transcription, DNA-templated and signal transduction. Acts upstream of or within BMP signaling pathway and cell adhesion. Located in endoplasmic reticulum-Golgi intermediate compartment. Is anchored component of plasma membrane. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and skeleton. Orthologous to human RGMB (repulsive guidance molecule BMP co-receptor b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 29.6), colon adult (RPKM 24.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A2; 17 8.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (16024923..16051508, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (15804661..15831246, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory role of RGMb in lung injury promoted by the combination of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and p38 MAPK pathways.
Title: Regulatory role of RGMb in lung injury promoted by the combination of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and p38 MAPK pathways.
These results demonstrate an important role for a novel innate pathway in regulating type 2 inflammation in patients with allergic asthma involving RGMb and RGMb-expressing cells, such as interstitial macrophages and bronchial epithelial cells. Moreover, targeting this previously unappreciated innate pathway might provide an important treatment option for allergic asthma.
Title: Blockade of RGMb inhibits allergen-induced airways disease.
These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses, but also a novel approach to investigate the B7-DC/PD-1/RGMb axis.
Title: B7-DC (PD-L2) costimulation of CD4(+) T-helper 1 response via RGMb.
Specific knockout of Rgmb in tubular cells increased MLKL expression at the apical membrane of proximal tubular cells and induced more tubular cell death and more severe renal dysfunction compared with wild-type mice.
Title: RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism.
Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher.
Title: Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.
These results reveal RGMb as a novel regulator for Autosomal dominant polycystic kidney disease by promoting renal tubule branching and regulating BMP signaling pathway.
Title: Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway.
The results indicate that RGMB-neogenin-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the developing olfactory epithelium.
Title: RGMB and neogenin control cell differentiation in the developing olfactory epithelium.
Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients.
Title: Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.
Title: RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.
Dragon may impair tubular epithelial integrity and induce epithelial apoptosis both in vitro and in vivo.
Title: Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

Rgmb (e-PCR), detects polymorphism
- UniSTS:508018

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: repulsive guidance molecule B

Names: DRG11-responsive axonal guidance and outgrowth of neurite; RGM domain family, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372256.1 → NP_001359185.1 repulsive guidance molecule B isoform 1

Status: VALIDATED

Source sequence(s)

AC102745

Conserved Domains (2) summary

pfam06534
Location:270 → 444

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:98 → 265

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001372257.1 → NP_001359186.1 repulsive guidance molecule B isoform 1

Status: VALIDATED

Source sequence(s)

AC102745

Conserved Domains (2) summary

pfam06534
Location:270 → 444

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:98 → 265

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001372258.1 → NP_001359187.1 repulsive guidance molecule B isoform 1

Status: VALIDATED

Source sequence(s)

AC102745

Conserved Domains (2) summary

pfam06534
Location:270 → 444

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:98 → 265

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001372259.1 → NP_001359188.1 repulsive guidance molecule B isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC102745

Consensus CDS

CCDS37455.1

UniProtKB/Swiss-Prot

Q501K0, Q7TQ33, Q8BNR6, Q8CBM7

UniProtKB/TrEMBL

Q8BSW1

Conserved Domains (2) summary

pfam06534
Location:229 → 403

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:57 → 224

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001372292.1 → NP_001359221.1 repulsive guidance molecule B isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC102745

UniProtKB/TrEMBL

A0A338P760

Related

ENSMUSP00000156285.2, ENSMUST00000232638.2

Conserved Domains (1) summary

pfam06535
Location:57 → 218

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_178615.4 → NP_848730.2 repulsive guidance molecule B isoform 2 precursor

See identical proteins and their annotated locations for NP_848730.2

Status: VALIDATED

Source sequence(s)

AC102745

Consensus CDS

CCDS37455.1

UniProtKB/Swiss-Prot

Q501K0, Q7TQ33, Q8BNR6, Q8CBM7

UniProtKB/TrEMBL

Q8BSW1

Related

ENSMUSP00000126177.2, ENSMUST00000170578.3

Conserved Domains (2) summary

pfam06534
Location:229 → 403

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:57 → 224

RGM_N; Repulsive guidance molecule (RGM) N-terminus