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Ddi2 DNA-damage inducible protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68817, updated on 25-May-2024

Summary

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Official Symbol
Ddi2provided by MGI
Official Full Name
DNA-damage inducible protein 2provided by MGI
Primary source
MGI:MGI:1917244
See related
Ensembl:ENSMUSG00000078515 AllianceGenome:MGI:1917244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110056G13Rik; 1700027M01Rik; 9130022E05Rik
Summary
Predicted to enable aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Predicted to be located in cytosol and nucleoplasm. Is expressed in brain. Orthologous to human DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 38.6), bladder adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ddi2 in Genome Data Viewer
Location:
4 D3; 4 74.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141410874..141450730, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141683563..141723419, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:141180986-141181286 Neighboring gene solute carrier family 25, member 34 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 2 Neighboring gene predicted gene, 54266 Neighboring gene STARR-seq mESC enhancer starr_11927 Neighboring gene regulatory solute carrier protein, family 1, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11263 Neighboring gene predicted gene, 34863 Neighboring gene STARR-seq mESC enhancer starr_11931 Neighboring gene agmatinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications. Liu Y, et al. Exp Cell Res, 2017 May 15. PMID 28322824
  2. The protease DDI2 regulates NRF1 activation in response to cadmium toxicity. Ribeiro ST, et al. iScience, 2022 Oct 21. PMID 36248746, Free PMC Article
  3. Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Ramirez J, et al. Hum Mol Genet, 2018 Jun 1. PMID 29788202
  4. Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation. Sha Z, et al. Curr Biol, 2016 Sep 26. PMID 27676298, Free PMC Article
  5. The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Koizumi S, et al. Elife, 2016 Aug 16. PMID 27528193, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aspartic-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein DDI1 homolog 2
NP_001017966.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017966.2 → NP_001017966.1  protein DDI1 homolog 2

    See identical proteins and their annotated locations for NP_001017966.1

    Status: VALIDATED

    Source sequence(s)
    AL671733, BF468816, BY731719, CD550969
    Consensus CDS
    CCDS18880.1
    UniProtKB/Swiss-Prot
    A2ADY9
    Related
    ENSMUSP00000099542.5, ENSMUST00000102484.5
    Conserved Domains (2) summary
    cd05479
    Location:221 → 343
    RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein
    cd01796
    Location:3 → 76
    DDI1_N; DNA damage inducible protein 1 ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141410874..141450730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ADY9.1 GenPept UniProtKB/Swiss-Prot:A2ADY9

Gene LinkOut

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