U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Usp21 ubiquitin specific peptidase 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688466, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Usp21provided by RGD
Official Full Name
ubiquitin specific peptidase 21provided by RGD
Primary source
RGD:1588822
See related
Ensembl:ENSRNOG00000038347 AllianceGenome:RGD:1588822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NEDD8-specific protease activity; thiol-dependent deubiquitinase; and transcription coactivator activity. Involved in neuron projection development. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 84.5), Spleen (RPKM 59.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Usp21 in Genome Data Viewer
Location:
13q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86235122..86241663, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83702672..83709215, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89655016..89661150, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene G protein subunit gamma 5, pseudogene 1 Neighboring gene death effector domain-containing

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. Gong L, et al. J Biol Chem, 2000 May 12. PMID 10799498
  2. Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation. Nakagawa T, et al. Genes Dev, 2008 Jan 1. PMID 18172164, Free PMC Article
  3. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. Khan A, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100909, Free PMC Article
  4. Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Urbé S, et al. Mol Biol Cell, 2012 Mar. PMID 22298430, Free PMC Article
  5. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI, et al. Int J Biochem Cell Biol, 2014 May. PMID 24647359

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate a key role for USP21 in the governance of microtubule- and centrosome-associated physiological processes.
    Title: Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC187584

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deNEDDylase activity IEA
Inferred from Electronic Annotation
more info
  
enables deNEDDylase activity ISO
Inferred from Sequence Orthology
more info
  
enables deNEDDylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase 21
Names
deubiquitinating enzyme 21
ubiquitin thioesterase 21
ubiquitin thiolesterase 21
ubiquitin-specific protease 21
ubiquitin-specific-processing protease 21
NP_001121110.1
XP_063128688.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127638.2 → NP_001121110.1  ubiquitin carboxyl-terminal hydrolase 21

    See identical proteins and their annotated locations for NP_001121110.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    B2GUX4
    UniProtKB/TrEMBL
    A0A8I6A1T1
    Related
    ENSRNOP00000055192.4, ENSRNOT00000058390.4
    Conserved Domains (2) summary
    cd02674
    Location:213 → 556
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:212 → 555
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    86235122..86241663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272618.1 → XP_063128688.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

RNA

  1. XR_010056937.1 RNA Sequence

  2. XR_010056938.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GUX4.1 GenPept UniProtKB/Swiss-Prot:B2GUX4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous