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Asb11 ankyrin repeat and SOCS box-containing 11 [ Mus musculus (house mouse) ]

Gene ID: 68854, updated on 5-Mar-2024

Summary

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Official Symbol
Asb11provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 11provided by MGI
Primary source
MGI:MGI:1916104
See related
Ensembl:ENSMUSG00000031382 AllianceGenome:MGI:1916104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110067L12Rik; 1600009D24Rik
Summary
Predicted to be involved in positive regulation of protein catabolic process and protein ubiquitination. Predicted to be located in endoplasmic reticulum. Orthologous to human ASB11 (ankyrin repeat and SOCS box containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 25.8), genital fat pad adult (RPKM 17.3) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
X F5; X 76.53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163219976..163242166)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164436953..164459170)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48238 Neighboring gene vascular endothelial growth factor D Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:160844233-160844342 Neighboring gene STARR-seq mESC enhancer starr_48240 Neighboring gene STARR-positive B cell enhancer ABC_E269 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A Neighboring gene chromobox protein homolog 1-like Neighboring gene ankyrin repeat and SOCS box-containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
  2. Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Richard AF, et al. Dev Biol, 2011 Nov 15. PMID 21884692
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 11
Names
ASB-11
ankyrin repeat and SOCS box-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313737.1 → NP_001300666.1  ankyrin repeat and SOCS box protein 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK005404, BU757326
    Consensus CDS
    CCDS85827.1
    UniProtKB/Swiss-Prot
    A2AIH7, Q3UJ13, Q9CQ31, Q9D0V1
    Related
    ENSMUSP00000044637.5, ENSMUST00000036858.11
    Conserved Domains (5) summary
    cd00204
    Location:66 → 183
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:102 → 189
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66 → 118
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    cl02533
    Location:282 → 323
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  2. NM_026853.2 → NP_081129.1  ankyrin repeat and SOCS box protein 11 isoform 2

    See identical proteins and their annotated locations for NP_081129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK004396, AK005404, AK078851, BU757326
    Consensus CDS
    CCDS30523.1
    UniProtKB/Swiss-Prot
    Q9CQ31
    Conserved Domains (3) summary
    sd00045
    Location:37 → 66
    ANK; ANK repeat [structural motif]
    cl02533
    Location:253 → 294
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:33 → 240
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    163219976..163242166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528972.5 → XP_006529035.2  ankyrin repeat and SOCS box protein 11 isoform X2

    Conserved Domains (3) summary
    sd00045
    Location:66 → 95
    ANK; ANK repeat [structural motif]
    cl02533
    Location:237 → 278
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:39 → 224
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006528971.5 → XP_006529034.2  ankyrin repeat and SOCS box protein 11 isoform X1

    Conserved Domains (3) summary
    PHA02874
    Location:69 → 243
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:129 → 157
    ANK; ANK repeat [structural motif]
    cl02533
    Location:246 → 287
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  3. XM_036162086.1 → XP_036017979.1  ankyrin repeat and SOCS box protein 11 isoform X3

    Related
    ENSMUSP00000033755.6, ENSMUST00000033755.6
    Conserved Domains (3) summary
    sd00045
    Location:37 → 66
    ANK; ANK repeat [structural motif]
    cl02533
    Location:253 → 294
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:33 → 240
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_030251494.2 → XP_030107354.1  ankyrin repeat and SOCS box protein 11 isoform X6

    Conserved Domains (3) summary
    sd00045
    Location:37 → 66
    ANK; ANK repeat [structural motif]
    cl02533
    Location:208 → 249
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:33 → 195
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_036162087.1 → XP_036017980.1  ankyrin repeat and SOCS box protein 11 isoform X5

    Conserved Domains (3) summary
    PHA02874
    Location:40 → 214
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:100 → 128
    ANK; ANK repeat [structural motif]
    cl02533
    Location:217 → 258
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  6. XM_006528974.5 → XP_006529037.1  ankyrin repeat and SOCS box protein 11 isoform X4

    Conserved Domains (3) summary
    sd00045
    Location:30 → 59
    ANK; ANK repeat [structural motif]
    cl02533
    Location:246 → 287
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:22 → 233
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ31.1 GenPept UniProtKB/Swiss-Prot:Q9CQ31

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