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Atg10 autophagy related 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688555, updated on 13-Apr-2024

Summary

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Official Symbol
Atg10provided by RGD
Official Full Name
autophagy related 10provided by RGD
Primary source
RGD:1587624
See related
Ensembl:ENSRNOG00000016342 AllianceGenome:RGD:1587624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Atg12 conjugating enzyme activity. Predicted to be involved in ER overload response; cellular protein modification process; and macroautophagy. Predicted to act upstream of or within positive regulation of protein modification process. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 28.6), Adrenal (RPKM 25.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (23843695..24133459, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (22109304..22398313, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (19853546..20152918, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485712 Neighboring gene ATPase H+ transporting accessory protein 1 like Neighboring gene ribosomal protein S23 Neighboring gene uncharacterized LOC120100664 Neighboring gene uncharacterized LOC134485814 Neighboring gene uncharacterized LOC134485572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. Shao Y, et al. Autophagy, 2007 Jan-Feb. PMID 16963840
  2. Inhibition of macroautophagy triggers apoptosis. Boya P, et al. Mol Cell Biol, 2005 Feb. PMID 15657430, Free PMC Article
  3. Regulation of autophagy by the inositol trisphosphate receptor. Criollo A, et al. Cell Death Differ, 2007 May. PMID 17256008
  4. The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. Nemoto T, et al. J Biol Chem, 2003 Oct 10. PMID 12890687
  5. Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. Mizushima N, et al. FEBS Lett, 2002 Dec 18. PMID 12482611

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Atg12 conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Atg12 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables Atg12 transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within positive regulation of protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification by small protein conjugation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-like-conjugating enzyme ATG10
Names
autophagy related 10 homolog
autophagy-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109505.2 → NP_001102975.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    See identical proteins and their annotated locations for NP_001102975.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GLV9, A6I4P1
    Related
    ENSRNOP00000097036.1, ENSRNOT00000095702.1
    Conserved Domains (1) summary
    pfam03987
    Location:11 → 205
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

  2. NM_001429163.1 → NP_001416092.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  3. NM_001429164.1 → NP_001416093.1  ubiquitin-like-conjugating enzyme ATG10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  4. NM_001429165.1 → NP_001416094.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    23843695..24133459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282566.1 → XP_063138636.1  ubiquitin-like-conjugating enzyme ATG10 isoform X5

  2. XM_063282568.1 → XP_063138638.1  ubiquitin-like-conjugating enzyme ATG10 isoform X8

  3. XM_063282567.1 → XP_063138637.1  ubiquitin-like-conjugating enzyme ATG10 isoform X7

  4. XM_063282569.1 → XP_063138639.1  ubiquitin-like-conjugating enzyme ATG10 isoform X9

  5. XM_039103148.2 → XP_038959076.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

    Conserved Domains (1) summary
    pfam03987
    Location:154 → 313
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

  6. XM_039103149.2 → XP_038959077.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLV9, D4A9K6
    Related
    ENSRNOP00000021942.4
    Conserved Domains (1) summary
    pfam03987
    Location:31 → 225
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

  7. XM_039103150.2 → XP_038959078.1  ubiquitin-like-conjugating enzyme ATG10 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GLV9, A6I4P1
    Conserved Domains (1) summary
    pfam03987
    Location:11 → 205
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

  8. XM_006231757.5 → XP_006231819.2  ubiquitin-like-conjugating enzyme ATG10 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GLV9
    Conserved Domains (1) summary
    pfam03987
    Location:30 → 224
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

  9. XM_039103153.2 → XP_038959081.1  ubiquitin-like-conjugating enzyme ATG10 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLV9
    Conserved Domains (1) summary
    pfam03987
    Location:22 → 181
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

  10. XM_063282570.1 → XP_063138640.1  ubiquitin-like-conjugating enzyme ATG10 isoform X10

  11. XM_063282571.1 → XP_063138641.1  ubiquitin-like-conjugating enzyme ATG10 isoform X11

RNA

  1. XR_010063662.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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