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Gngt2 G protein subunit gamma transducin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690825, updated on 30-Mar-2024

Summary

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Official Symbol
Gngt2provided by RGD
Official Full Name
G protein subunit gamma transducin 2provided by RGD
Primary source
RGD:1591007
See related
AllianceGenome:RGD:1591007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg3i
Summary
Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNGT2 (G protein subunit gamma transducin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 281.1), Heart (RPKM 100.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q26
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81271916..81280980)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (80776003..80784235)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83654321..83658601)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547047 Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 Neighboring gene ABI family, member 3 Neighboring gene uncharacterized LOC134480858 Neighboring gene transfer RNA glutamine (anticodon UUG) 1 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Huang L, et al. Nat Neurosci, 1999 Dec. PMID 10570481
  2. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY, et al. J Biol Chem, 2012 Jan 13. PMID 22074925, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Names
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein, gamma transducing activity polypeptide 2
heterotrimeric guanine nucleotide-binding protein 3i

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135767.1 → NP_001129239.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

    See identical proteins and their annotated locations for NP_001129239.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    81271916..81280980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086881.2 → XP_038942809.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  2. XM_006247208.5 → XP_006247270.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    See identical proteins and their annotated locations for XP_006247270.1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  3. XM_006247209.2 → XP_006247271.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    See identical proteins and their annotated locations for XP_006247271.1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  4. XM_039086882.1 → XP_038942810.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  5. XM_039086880.2 → XP_038942808.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  6. XM_039086879.2 → XP_038942807.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  7. XM_039086878.2 → XP_038942806.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    UniProtKB/TrEMBL
    A6HIB3, A6HIB8
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs
Nucleotide Protein Strain
Heading Accession and Version

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