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Serpine3 serpin family E member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691375, updated on 5-Mar-2024

Summary

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Official Symbol
Serpine3provided by RGD
Official Full Name
serpin family E member 3provided by RGD
Primary source
RGD:1585042
See related
Ensembl:ENSRNOG00000009814 AllianceGenome:RGD:1585042
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310515
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Orthologous to human SERPINE3 (serpin family E member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 38.2), Thymus (RPKM 37.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Serpine3 in Genome Data Viewer
Location:
15p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41084819..41109006)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (36908816..36931825)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (45827983..45855952)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 124 member A Neighboring gene uncharacterized LOC134482129 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L38, pseudogene 7 Neighboring gene integrator complex subunit 6 Neighboring gene Sec61 translocon subunit gamma, pseudogene 5 Neighboring gene zinc finger CCCH domain-containing protein 13-like Neighboring gene large ribosomal subunit protein eL27-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serpin E3
Names
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    41084819..41109006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274875.1 → XP_063130945.1  serpin E3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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