U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pla2g4c phospholipase A2 group IVC [ Rattus norvegicus (Norway rat) ]

Gene ID: 691810, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pla2g4cprovided by RGD
Official Full Name
phospholipase A2 group IVCprovided by RGD
Primary source
RGD:1594658
See related
Ensembl:ENSRNOG00000026764 AllianceGenome:RGD:1594658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pla2g4cl1; Pla2g4cl2
Summary
Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process and lipid droplet formation. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; lipid droplet; and mitochondrial membrane. Predicted to be active in cytosol; nuclear envelope; and nucleoplasm. Orthologous to human PLA2G4C (phospholipase A2 group IVC). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 22.5), Thymus (RPKM 16.1) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (83315017..83411342)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (74237714..74275757)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (75440035..75481995)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485101 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene DNA ligase 1 Neighboring gene pellino 1, pseudogene 1 Neighboring gene calcium binding protein 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PLA2 activity is required for nuclear shrinkage in caspase-independent cell death. Shinzawa K, et al. J Cell Biol, 2003 Dec 22. PMID 14676306, Free PMC Article
  2. Deletion of phospholipase A2 group IVc induces apoptosis in rat mammary tumour cells by the nuclear factor-κB/lipocalin 2 pathway. Nanashima N, et al. Biochem J, 2015 Jul 15. PMID 26013918
  3. Mouse cPLA2gamma, a novel oocyte and early embryo-abundant phospholipase A2 gamma-like protein, is targeted to the nuclear envelope during germinal vesicle breakdown. Vitale A, et al. Dev Biol, 2005 Jun 15. PMID 15950603
  4. Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. Pickard RT, et al. J Biol Chem, 1999 Mar 26. PMID 10085124
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This is the first report on Pla2g4c gene-deficient rats and their low susceptibility to mammary carcinogenesis by enhancing NF-kappaB/Lcn2-induced apoptosis.
    Title: Deletion of phospholipase A2 group IVc induces apoptosis in rat mammary tumour cells by the nuclear factor-κB/lipocalin 2 pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet activating factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytosolic phospholipase A2 gamma
Names
phospholipase A2, group IVC (cytosolic, calcium-independent)
phospholipase A2, group IVC-like 1
phospholipase A2, group IVC-like 2
NP_001380619.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393690.1 → NP_001380619.1  cytosolic phospholipase A2 gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LMQ4, F1LY61
    Related
    ENSRNOP00000055136.5, ENSRNOT00000058334.5
    Conserved Domains (1) summary
    cl11396
    Location:14 → 576
    Patatin_and_cPLA2; Patatins and Phospholipases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    83315017..83411342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001145982.1: Suppressed sequence

    Description
    NM_001145982.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.