U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Maz MYC associated zinc finger protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 691842, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Mazprovided by RGD
Official Full Name
MYC associated zinc finger proteinprovided by RGD
Primary source
RGD:1594632
See related
Ensembl:ENSRNOG00000055082 AllianceGenome:RGD:1594632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pur-1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human MAZ (MYC associated zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 197.3), Spleen (RPKM 80.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Maz in Genome Data Viewer
Location:
1q37
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191060271..191065722, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181629742..181635193, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198456699..198460126, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene major vault protein Neighboring gene Paxip1-associated glutamate-rich protein 1 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene uncharacterized LOC134483860 Neighboring gene kinesin family member 22 Neighboring gene uncharacterized LOC108349644 Neighboring gene zymogen granule protein 16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. Himeda CL, et al. Mol Cell Biol, 2008 Oct. PMID 18710939, Free PMC Article
  2. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Bossone SA, et al. Proc Natl Acad Sci U S A, 1992 Aug 15. PMID 1502157, Free PMC Article
  3. MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein. Yao Y, et al. Mol Oncol, 2015 Mar. PMID 25487955, Free PMC Article
  4. Characterization of the murine Ephrin-B2 promoter. Sohl M, et al. Gene, 2009 May 15. PMID 19268698
  5. Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Ugai H, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527412

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings are consistent with a previously unrecognized role for MAZ in muscle gene regulation.
    Title: Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of RNA polymerase II transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myc-associated zinc finger protein
Names
purine-binding transcription factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110319.2 → NP_001103789.1  myc-associated zinc finger protein

    See identical proteins and their annotated locations for NP_001103789.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K0R4, A8QJL8
    Related
    ENSRNOP00000071552.2, ENSRNOT00000086019.2
    Conserved Domains (3) summary
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:337 → 357
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:293 → 318
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191060271..191065722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091680.2 → XP_038947608.1  myc-associated zinc finger protein isoform X3

    UniProtKB/TrEMBL
    A0A0G2KAJ3
    Related
    ENSRNOP00000075418.2
    Conserved Domains (3) summary
    COG5048
    Location:254 → 302
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:280 → 337
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_063274925.1 → XP_063130995.1  myc-associated zinc finger protein isoform X2

  3. XM_039091677.2 → XP_038947605.1  myc-associated zinc finger protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBK6
    Conserved Domains (2) summary
    COG5189
    Location:303 → 360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_039091685.2 → XP_038947613.1  myc-associated zinc finger protein isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:277 → 325
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:303 → 360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous