Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox10provided by RGD
Official Full Name: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10provided by RGD
Primary source: RGD:1594623
See related: Ensembl:ENSRNOG00000024972 AllianceGenome:RGD:1594623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable farnesyltranstransferase activity. Predicted to be involved in cellular respiration; heme biosynthetic process; and respiratory chain complex IV assembly. Predicted to act upstream of or within several processes, including cytochrome complex assembly; heme A biosynthetic process; and mitochondrial fission. Predicted to be located in cytosol and nucleolus. Predicted to be part of cytochrome complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 135.1), Muscle (RPKM 106.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (49130209..49242009, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (48630993..48742805, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (50439778..50563920, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Cox10 (e-PCR), detects polymorphism
- UniSTS:527290

AI229478 (e-PCR)
- UniSTS:250601

RH134824 (e-PCR)
- UniSTS:218102

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables farnesyltranstransferase activity	ISO Inferred from Sequence Orthology more info
enables protoheme IX farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protoheme IX farnesyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aerobic respiration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytochrome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in heme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme O biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in respiratory chain complex IV assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cytochrome complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

Names: COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; cytochrome c oxidase assembly homolog 10; protoheme IX farnesyltransferase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398997.1 → NP_001385926.1 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HFE3

Related

ENSRNOP00000029439.5, ENSRNOT00000034261.6

Conserved Domains (1) summary

cd13957
Location:158 → 413

PT_UbiA_Cox10; Protoheme IX farnesyltransferase