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TCEA3 transcription elongation factor A3 [ Homo sapiens (human) ]

Gene ID: 6920, updated on 3-Apr-2024

Summary

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Official Symbol
TCEA3provided by HGNC
Official Full Name
transcription elongation factor A3provided by HGNC
Primary source
HGNC:HGNC:11615
See related
Ensembl:ENSG00000204219 MIM:604128; AllianceGenome:HGNC:11615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIS; TFIIS.H
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated and transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 19.3), ovary (RPKM 18.5) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23380909..23424748, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23214086..23259235, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23707402..23751241, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23670710-23671294 Neighboring gene MIR1 retrotransposon enhancer-blocking element Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23683836-23684671 Neighboring gene Sharpr-MPRA regulatory region 11811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 361 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23697210-23697795 Neighboring gene ZNF436 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 362 Neighboring gene zinc finger protein 436 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23709609-23709825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 363 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23745635-23746193 Neighboring gene uncharacterized LOC124903875 Neighboring gene Sharpr-MPRA regulatory region 12987 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23800831-23801332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23801333-23801832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23829854-23830688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23830689-23831522 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:23847293-23848492 Neighboring gene uncharacterized LOC101928163 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23854779-23854975 Neighboring gene E2F transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma. Kazim N, et al. Cell Death Dis, 2020 Jan 27. PMID 31988307, Free PMC Article
  2. TCEA3 Attenuates Gastric Cancer Growth by Apoptosis Induction. Li J, et al. Med Sci Monit, 2015 Oct 26. PMID 26498664, Free PMC Article
  3. TCEA3 binds to TGF-beta receptor I and induces Smad-independent, JNK-dependent apoptosis in ovarian cancer cells. Cha Y, et al. Cell Signal, 2013 May. PMID 23357533
  4. USP47-Mediated Deubiquitination and Stabilization of TCEA3 Attenuates Pyroptosis and Apoptosis of Colorectal Cancer Cells Induced by Chemotherapeutic Doxorubicin. Hou X, et al. Front Pharmacol, 2021. PMID 34630087, Free PMC Article
  5. TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. Liao JM, et al. Sci Rep, 2016 Mar 23. PMID 27005522, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma.
    Title: The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma.
  2. Findings reveal a novel mechanism by which p53 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging cell death in response to severe DNA damage.
    Title: TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene.
  3. TCEA3 attenuates the proliferation and induces apoptosis of gastric cancer cells
    Title: TCEA3 Attenuates Gastric Cancer Growth by Apoptosis Induction.
  4. Tcea3 binds to TGF-beta I receptor and activates TGF-beta signaling pathway.
    Title: TCEA3 binds to TGF-beta receptor I and induces Smad-independent, JNK-dependent apoptosis in ovarian cancer cells.
  5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  7. Study demonstrates a strong synergy between hPAF1C and elongation factor SII/TFIIS and an underlying mechanism involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II.
    Title: The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein 3
Names
rhabdomyosarcoma antigen MU-RMS-40.22
transcription elongation factor A (SII), 3
transcription elongation factor S-II protein 3
transcription elongation factor TFIIS.h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003196.3 → NP_003187.1  transcription elongation factor A protein 3

    See identical proteins and their annotated locations for NP_003187.1

    Status: VALIDATED

    Source sequence(s)
    AA873235, AK290272, AK300707, AL109936, BE880226, BI835458, BQ003897, CU449151, HY070786
    Consensus CDS
    CCDS44086.1
    UniProtKB/Swiss-Prot
    A8K2K7, O75764, Q5DR83
    UniProtKB/TrEMBL
    S4R3M9
    Related
    ENSP00000406293.2, ENST00000450454.7
    Conserved Domains (1) summary
    cl02637
    Location:5 → 348
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23380909..23424748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542053.4 → XP_011540355.1  transcription elongation factor A protein 3 isoform X5

    UniProtKB/TrEMBL
    S4R3M9
    Conserved Domains (1) summary
    cl02637
    Location:5 → 346
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  2. XM_017002201.2 → XP_016857690.1  transcription elongation factor A protein 3 isoform X2

  3. XM_017002202.3 → XP_016857691.1  transcription elongation factor A protein 3 isoform X3

  4. XM_006710864.3 → XP_006710927.1  transcription elongation factor A protein 3 isoform X6

    UniProtKB/TrEMBL
    S4R3M9
    Related
    ENSP00000474530.3, ENST00000476978.3
    Conserved Domains (4) summary
    cd00183
    Location:4 → 80
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:301 → 346
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:5 → 346
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:185 → 292
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  5. XM_017002200.3 → XP_016857689.1  transcription elongation factor A protein 3 isoform X1

  6. XM_017002203.2 → XP_016857692.1  transcription elongation factor A protein 3 isoform X4

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p14 PATCHES

    Range
    150888..194727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331930.1 → XP_054187905.1  transcription elongation factor A protein 3 isoform X5

  2. XM_054331927.1 → XP_054187902.1  transcription elongation factor A protein 3 isoform X2

  3. XM_054331928.1 → XP_054187903.1  transcription elongation factor A protein 3 isoform X3

  4. XM_054331931.1 → XP_054187906.1  transcription elongation factor A protein 3 isoform X6

  5. XM_054331926.1 → XP_054187901.1  transcription elongation factor A protein 3 isoform X1

  6. XM_054331929.1 → XP_054187904.1  transcription elongation factor A protein 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23214086..23259235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338525.1 → XP_054194500.1  transcription elongation factor A protein 3 isoform X5

  2. XM_054338522.1 → XP_054194497.1  transcription elongation factor A protein 3 isoform X2

  3. XM_054338523.1 → XP_054194498.1  transcription elongation factor A protein 3 isoform X3

  4. XM_054338526.1 → XP_054194501.1  transcription elongation factor A protein 3 isoform X6

  5. XM_054338521.1 → XP_054194496.1  transcription elongation factor A protein 3 isoform X1

  6. XM_054338524.1 → XP_054194499.1  transcription elongation factor A protein 3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75764.2 GenPept UniProtKB/Swiss-Prot:O75764

Gene LinkOut

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