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ZEB1 zinc finger E-box binding homeobox 1 [ Homo sapiens (human) ]

Gene ID: 6935, updated on 7-Apr-2024

Summary

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Official Symbol
ZEB1provided by HGNC
Official Full Name
zinc finger E-box binding homeobox 1provided by HGNC
Primary source
HGNC:HGNC:11642
See related
Ensembl:ENSG00000148516 MIM:189909; AllianceGenome:HGNC:11642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
Summary
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in endometrium (RPKM 12.8), brain (RPKM 12.1) and 23 other tissues See more
Orthologs
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Genomic context

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See ZEB1 in Genome Data Viewer
Location:
10p11.22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (31318417..31529804)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (31348155..31559554)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (31607346..31818732)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376481 Neighboring gene uncharacterized LOC105376482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2272 Neighboring gene uncharacterized LOC105376483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435102-31435653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435654-31436204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31498085-31498585 Neighboring gene long intergenic non-protein coding RNA 2664 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:31531588-31532787 Neighboring gene RNA, 5S ribosomal pseudogene 309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3236 Neighboring gene ZEB1 antisense RNA 1 Neighboring gene POM121 transmembrane nucleoporin like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3239 Neighboring gene serine palmitoyltransferase long chain base subunit 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:31756459-31756960 Neighboring gene Sharpr-MPRA regulatory region 3516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3240 Neighboring gene MPRA-validated peak919 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31797084-31797592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31797593-31798099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31873359-31873859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2277 Neighboring gene uncharacterized LOC105376484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3241 Neighboring gene glutamate dehydrogenase 1 pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31954277-31955148 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31955149-31956018 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:31966287-31966838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31983575-31984136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31984137-31984698 Neighboring gene macrophage enriched lincRNA repressor of IFN-gamma signaling

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis.
    Title: ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis.
  2. ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.
    Title: ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.
  3. Loss-of-function variants in ZEB1 cause dominant anomalies of the corpus callosum with favourable cognitive prognosis.
    Title: Loss-of-function variants in ZEB1 cause dominant anomalies of the corpus callosum with favourable cognitive prognosis.
  4. miR-186 regulates epithelial-mesenchymal transformation to promote nasopharyngeal carcinoma metastasis by targeting ZEB1.
    Title: miR-186 regulates epithelial-mesenchymal transformation to promote nasopharyngeal carcinoma metastasis by targeting ZEB1.
  5. Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPalpha axis.
    Title: Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis.
  6. miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway.
    Title: miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway.
  7. ZEB1 hypermethylation is associated with better prognosis in patients with colon cancer.
    Title: ZEB1 hypermethylation is associated with better prognosis in patients with colon cancer.
  8. lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to Promote the Epithelial-Mesenchymal Transition of Cervical Cancer Cells.
    Title: lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to Promote the Epithelial-Mesenchymal Transition of Cervical Cancer Cells.
  9. The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.
    Title: The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.
  10. Loss of Key EMT-Regulating miRNAs Highlight the Role of ZEB1 in EGFR Tyrosine Kinase Inhibitor-Resistant NSCLC.
    Title: Loss of Key EMT-Regulating miRNAs Highlight the Role of ZEB1 in EGFR Tyrosine Kinase Inhibitor-Resistant NSCLC.
Submit: New GeneRIF Correction See all GeneRIFs (580)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Corneal dystrophy, Fuchs endothelial, 6
MedGen: C2750448 OMIM: 613270 GeneReviews: Not available
Compare labs
Posterior polymorphous corneal dystrophy 3
MedGen: C1836724 OMIM: 609141 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef upregulates the expression of transcription factor 8 in HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cartilage development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cochlea morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
  
involved_in semicircular canal morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger E-box-binding homeobox 1
Names
delta-crystallin enhancer binding factor 1
negative regulator of IL2
posterior polymorphous corneal dystrophy 3
transcription factor 8 (represses interleukin 2 expression)
zinc finger homeodomain enhancer-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017048.2 RefSeqGene

    Range
    5801..216389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128128.3 → NP_001121600.1  zinc finger E-box-binding homeobox 1 isoform a

    See identical proteins and their annotated locations for NP_001121600.1

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Consensus CDS
    CCDS44370.1
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000391612.2, ENST00000446923.7
    Conserved Domains (5) summary
    smart00389
    Location:577 → 613
    HOX; Homeodomain
    COG5271
    Location:1 → 181
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00017
    Location:890 → 910
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224 → 246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:930 → 955
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001174093.2 → NP_001167564.1  zinc finger E-box-binding homeobox 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AI086650, AL831979, BC112392, BQ003893, BX111519, DC299346
    Consensus CDS
    CCDS53506.1
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000452787.1, ENST00000560721.6
    Conserved Domains (5) summary
    smart00389
    Location:573 → 609
    HOX; Homeodomain
    COG5048
    Location:909 → 962
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:886 → 906
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:926 → 951
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001174094.2 → NP_001167565.1  zinc finger E-box-binding homeobox 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AI086650, AK311116, AK311187, AK311557, AK314683, AL831979, BQ003893, BX111519, U12170
    UniProtKB/TrEMBL
    B2RBI8
    Conserved Domains (5) summary
    smart00389
    Location:576 → 612
    HOX; Homeodomain
    COG5271
    Location:1 → 180
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00017
    Location:889 → 909
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:223 → 245
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:929 → 954
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001174095.2 → NP_001167566.1  zinc finger E-box-binding homeobox 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AI086650, AK300830, AK314683, AL831979, BQ003893, BX111519, DC299346, U12170
    Consensus CDS
    CCDS53507.1
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000444891.2, ENST00000542815.7
    Conserved Domains (5) summary
    smart00389
    Location:526 → 562
    HOX; Homeodomain
    COG5048
    Location:862 → 915
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:839 → 859
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:173 → 195
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:879 → 904
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001174096.2 → NP_001167567.1  zinc finger E-box-binding homeobox 1 isoform f

    See identical proteins and their annotated locations for NP_001167567.1

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Consensus CDS
    CCDS53505.1
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000415961.2, ENST00000424869.6
    Conserved Domains (4) summary
    smart00389
    Location:594 → 630
    HOX; Homeodomain
    sd00017
    Location:907 → 927
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 263
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:947 → 972
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001323638.2 → NP_001310567.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL161935, AL355148, BX647794
    UniProtKB/TrEMBL
    B4DGU2
    Related
    ENST00000488625.6
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001323641.2 → NP_001310570.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AK294775, AL161935
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001323642.2 → NP_001310571.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001323643.2 → NP_001310572.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001323644.2 → NP_001310573.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  11. NM_001323645.2 → NP_001310574.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  12. NM_001323646.2 → NP_001310575.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AK311372, AL117340, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  13. NM_001323647.2 → NP_001310576.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  14. NM_001323648.2 → NP_001310577.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  15. NM_001323649.2 → NP_001310578.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  16. NM_001323650.2 → NP_001310579.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  17. NM_001323651.2 → NP_001310580.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AK307510, AL158080, AL161935
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  18. NM_001323652.2 → NP_001310581.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL161935, AL355148, DB276952
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  19. NM_001323653.2 → NP_001310582.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL161935, AL355148, AL831979
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  20. NM_001323654.2 → NP_001310583.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AK308822, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  21. NM_001323655.2 → NP_001310584.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL161935, AL355148, BX954549
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  22. NM_001323656.2 → NP_001310585.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  23. NM_001323657.2 → NP_001310586.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  24. NM_001323658.2 → NP_001310587.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL161935, AL355148, DC403144
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  25. NM_001323659.2 → NP_001310588.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  26. NM_001323660.2 → NP_001310589.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  27. NM_001323661.2 → NP_001310590.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AK309399, AL158080, AL161935, AL355148, DC375708
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  28. NM_001323662.2 → NP_001310591.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  29. NM_001323663.2 → NP_001310592.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  30. NM_001323664.2 → NP_001310593.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  31. NM_001323665.2 → NP_001310594.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  32. NM_001323666.2 → NP_001310595.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  33. NM_001323671.2 → NP_001310600.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  34. NM_001323672.2 → NP_001310601.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  35. NM_001323673.2 → NP_001310602.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375 → 411
    HOX; Homeodomain
    sd00017
    Location:688 → 708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:22 → 44
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728 → 753
    zf-H2C2_2; Zinc-finger double domain

  36. NM_001323674.2 → NP_001310603.1  zinc finger E-box-binding homeobox 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B2RBI8

  37. NM_001323675.2 → NP_001310604.1  zinc finger E-box-binding homeobox 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B2RBI8

  38. NM_001323676.2 → NP_001310605.1  zinc finger E-box-binding homeobox 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B2RBI8

  39. NM_001323677.2 → NP_001310606.1  zinc finger E-box-binding homeobox 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B2RBI8

  40. NM_001323678.2 → NP_001310607.1  zinc finger E-box-binding homeobox 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    UniProtKB/TrEMBL
    B2RBI8

  41. NM_030751.6 → NP_110378.3  zinc finger E-box-binding homeobox 1 isoform b

    See identical proteins and their annotated locations for NP_110378.3

    Status: REVIEWED

    Source sequence(s)
    AI086650, AK314683, AL831979, BQ003893, BX111519, U12170
    Consensus CDS
    CCDS7169.1
    UniProtKB/Swiss-Prot
    B4DJV0, B4DUW9, E9PCM7, F5H4I8, P37275, Q12924, Q13800, Q2KJ05, Q5T968, Q5VZ84, Q8NB68
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000319248.9, ENST00000320985.14
    Conserved Domains (5) summary
    smart00389
    Location:593 → 629
    HOX; Homeodomain
    COG5271
    Location:27 → 197
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00017
    Location:906 → 926
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240 → 262
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:946 → 971
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    31318417..31529804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425691.1 → XP_047281647.1  zinc finger E-box-binding homeobox 1 isoform X1

  2. XM_047425695.1 → XP_047281651.1  zinc finger E-box-binding homeobox 1 isoform X1

  3. XM_047425684.1 → XP_047281640.1  zinc finger E-box-binding homeobox 1 isoform X1

  4. XM_047425689.1 → XP_047281645.1  zinc finger E-box-binding homeobox 1 isoform X1

  5. XM_047425685.1 → XP_047281641.1  zinc finger E-box-binding homeobox 1 isoform X1

  6. XM_047425688.1 → XP_047281644.1  zinc finger E-box-binding homeobox 1 isoform X1

  7. XM_047425696.1 → XP_047281652.1  zinc finger E-box-binding homeobox 1 isoform X1

  8. XM_047425687.1 → XP_047281643.1  zinc finger E-box-binding homeobox 1 isoform X1

  9. XM_047425694.1 → XP_047281650.1  zinc finger E-box-binding homeobox 1 isoform X1

  10. XM_047425686.1 → XP_047281642.1  zinc finger E-box-binding homeobox 1 isoform X1

  11. XM_047425690.1 → XP_047281646.1  zinc finger E-box-binding homeobox 1 isoform X1

  12. XM_047425692.1 → XP_047281648.1  zinc finger E-box-binding homeobox 1 isoform X1

  13. XM_047425683.1 → XP_047281639.1  zinc finger E-box-binding homeobox 1 isoform X1

  14. XM_047425682.1 → XP_047281638.1  zinc finger E-box-binding homeobox 1 isoform X1

  15. XM_047425693.1 → XP_047281649.1  zinc finger E-box-binding homeobox 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    31348155..31559554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366657.1 → XP_054222632.1  zinc finger E-box-binding homeobox 1 isoform X1

  2. XM_054366661.1 → XP_054222636.1  zinc finger E-box-binding homeobox 1 isoform X1

  3. XM_054366650.1 → XP_054222625.1  zinc finger E-box-binding homeobox 1 isoform X1

  4. XM_054366655.1 → XP_054222630.1  zinc finger E-box-binding homeobox 1 isoform X1

  5. XM_054366651.1 → XP_054222626.1  zinc finger E-box-binding homeobox 1 isoform X1

  6. XM_054366654.1 → XP_054222629.1  zinc finger E-box-binding homeobox 1 isoform X1

  7. XM_054366662.1 → XP_054222637.1  zinc finger E-box-binding homeobox 1 isoform X1

  8. XM_054366653.1 → XP_054222628.1  zinc finger E-box-binding homeobox 1 isoform X1

  9. XM_054366660.1 → XP_054222635.1  zinc finger E-box-binding homeobox 1 isoform X1

  10. XM_054366652.1 → XP_054222627.1  zinc finger E-box-binding homeobox 1 isoform X1

  11. XM_054366656.1 → XP_054222631.1  zinc finger E-box-binding homeobox 1 isoform X1

  12. XM_054366658.1 → XP_054222633.1  zinc finger E-box-binding homeobox 1 isoform X1

  13. XM_054366649.1 → XP_054222624.1  zinc finger E-box-binding homeobox 1 isoform X1

  14. XM_054366648.1 → XP_054222623.1  zinc finger E-box-binding homeobox 1 isoform X1

  15. XM_054366659.1 → XP_054222634.1  zinc finger E-box-binding homeobox 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37275.2 GenPept UniProtKB/Swiss-Prot:P37275

Gene LinkOut

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