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Clic3 chloride intracellular channel 3 [ Mus musculus (house mouse) ]

Gene ID: 69454, updated on 12-May-2024

Summary

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Official Symbol
Clic3provided by MGI
Official Full Name
chloride intracellular channel 3provided by MGI
Primary source
MGI:MGI:1916704
See related
Ensembl:ENSMUSG00000015093 AllianceGenome:MGI:1916704
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2300003G24Rik
Summary
Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in nuclear body. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC3 (chloride intracellular channel 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 601.4), stomach adult (RPKM 133.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Clic3 in Genome Data Viewer
Location:
2 A3; 2 17.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25346855..25348789)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25456843..25458777)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 7 Neighboring gene ATP-binding cassette, sub-family A member 2 Neighboring gene microRNA 3087 Neighboring gene STARR-positive B cell enhancer ABC_E2604 Neighboring gene non-homologous end joining factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25321339-25321522 Neighboring gene prostaglandin D2 synthase (brain) Neighboring gene predicted gene, 35287

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner. Kim KH, et al. Eur J Immunol, 2013 Mar. PMID 23280470
  2. Molecular detection of maturation stages in the developing kidney. Naganuma H, et al. Dev Biol, 2021 Feb. PMID 33197428
  3. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Lefebvre J, et al. Kidney Int, 2015 Aug. PMID 25993318
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
    Title: CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chloride intracellular channel protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027085.3 → NP_081361.1  chloride intracellular channel protein 3

    See identical proteins and their annotated locations for NP_081361.1

    Status: PROVISIONAL

    Source sequence(s)
    AL732557
    Consensus CDS
    CCDS15774.1
    UniProtKB/Swiss-Prot
    Q9D7P7
    UniProtKB/TrEMBL
    A2AJ28
    Related
    ENSMUSP00000109904.3, ENSMUST00000114265.9
    Conserved Domains (3) summary
    TIGR00862
    Location:6 → 230
    O-ClC; intracellular chloride channel protein
    cd10299
    Location:99 → 231
    GST_C_CLIC3; C-terminal, alpha helical domain of Chloride Intracellular Channel 3
    cd03061
    Location:3 → 92
    GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25346855..25348789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252050.2 → XP_030107910.1  chloride intracellular channel protein 3 isoform X1

    UniProtKB/TrEMBL
    A2AJ28
    Conserved Domains (1) summary
    TIGR00862
    Location:43 → 261
    O-ClC; intracellular chloride channel protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7P7.2 GenPept UniProtKB/Swiss-Prot:Q9D7P7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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