Dab2ip disabled 2 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dab2ipprovided by MGI
Official Full Name: disabled 2 interacting proteinprovided by MGI
Primary source: MGI:MGI:1916851
See related: Ensembl:ENSMUSG00000026883 AllianceGenome:MGI:1916851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aip1; mKIAA1743; 2310011D08Rik
Summary: Enables protein kinase binding activity. Involved in several processes, including cellular response to cytokine stimulus; neurogenesis; and regulation of signal transduction. Located in axon; cytoplasm; and neuronal cell body membrane. Part of AIP1-IRE1 complex. Is expressed in cartilage; telencephalon; and trigeminal ganglion. Orthologous to human DAB2IP (DAB2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 34.6), lung adult (RPKM 31.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 23.74 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (35448285..35621006)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (35558446..35730994)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAB2IP-knocking down resulted in radio-resistance of breast cancer cells is associated with increased hypoxia and vasculogenic mimicry formation.
Title: DAB2IP-knocking down resulted in radio-resistance of breast cancer cells is associated with increased hypoxia and vasculogenic mimicry formation.
AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model.
Title: AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model.
Astaxanthin mediated regulation of VEGF through HIF1alpha and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model.
Title: Astaxanthin mediated regulation of VEGF through HIF1α and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model.
MicroRNA-146b-5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38-Mapk pathway and gammaH2A.X phosphorylation.
Title: MicroRNA-146b-5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38-Mapk pathway and γH2A.X phosphorylation.
PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
Title: DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1α protein.
DAB2IP loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates prostate cancer cell survival from androgen deprivation therapy-induced cell death.
Title: DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis.
Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells.
Title: AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment.
Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.
Title: Single-molecule imaging of a three-component ordered actin disassembly mechanism.
results suggest that Dab2IP plays an important role in the migration and positioning of a subpopulation of later-born (layers II-IV) neurons, likely through the regulation of Rap1 and integrin signaling.
Title: Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.
Our data reveal that AIP1, by inhibiting VEGFR2-dependent signaling in tumor niche, suppresses tumor EMT switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis.
Title: AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

10.MMHAP27FRD7.seq (e-PCR)
- UniSTS:123020

D2Mit319 (e-PCR), detects polymorphism
- UniSTS:129212

RH35818 (e-PCR)
- UniSTS:58857

AI480459 (e-PCR)
- UniSTS:158961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
NOT enables Toll-like receptor 4 binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell motility involved in cerebral cortex radial glia guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in layer formation in cerebral cortex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tube formation	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AIP1-IRE1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of AIP1-IRE1 complex	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cerebellar mossy fiber	IDA Inferred from Direct Assay more info	PubMed
located_in climbing fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in parallel fiber	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disabled homolog 2-interacting protein

Names: ASK-interacting protein 1; ASK1-interacting protein 1; DAB2-interacting protein; DOC-2/DAB-2 interactive protein; disabled 2 interacting protein long form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001602.2 → NP_001001602.2 disabled homolog 2-interacting protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 2.

Source sequence(s)

AK147593, AL929241, BC118530, BP758326

Consensus CDS

CCDS15965.2

UniProtKB/TrEMBL

A2AUX5, F6RK07

Related

ENSMUSP00000068832.6, ENSMUST00000065001.12

Conserved Domains (6) summary

cd04013
Location:138 → 277

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:268 → 591

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

smart00323
Location:263 → 581

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam07106
Location:963 → 1051

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam12004
Location:581 → 1085

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:56 → 196

PH-like; Pleckstrin homology-like domain
NM_001114124.2 → NP_001107596.1 disabled homolog 2-interacting protein isoform 2

See identical proteins and their annotated locations for NP_001107596.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AK147464, AK147593, BC094373

Consensus CDS

CCDS50578.1

UniProtKB/Swiss-Prot

A2AUW9, A2AUX2, A5X2X2, B7ZD28, Q3TPD5, Q3UH44, Q3UHC7, Q6JTV1, Q6Y636, Q80T97

UniProtKB/TrEMBL

F6RK07

Related

ENSMUSP00000088532.6, ENSMUST00000091010.12

Conserved Domains (6) summary

cd04013
Location:203 → 342

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:333 → 656

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

smart00323
Location:328 → 646

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam07106
Location:1028 → 1116

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam12004
Location:646 → 1150

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:75 → 261

PH-like; Pleckstrin homology-like domain
NM_001114125.1 → NP_001107597.1 disabled homolog 2-interacting protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, and it also lacks a 3' segment that results in an alternate 3' coding region, compared to variant 2. The encoded isoform (1) has distinct N- and C-termini and is shorter than isoform 2.

Source sequence(s)

AL929076, AL929241

Consensus CDS

CCDS50577.1

UniProtKB/TrEMBL

F6RK07

Related

ENSMUSP00000108610.3, ENSMUST00000112986.9

Conserved Domains (6) summary

cd04013
Location:175 → 314

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:305 → 628

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

smart00323
Location:300 → 618

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam07106
Location:1000 → 1088

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam12004
Location:618 → 1122

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:47 → 233

PH-like; Pleckstrin homology-like domain
NM_001290637.1 → NP_001277566.1 disabled homolog 2-interacting protein isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, and it also lacks a 3' segment that results in an alternate 3' coding region, compared to variant 2. The encoded isoform (4) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AL929241, BC094373

Consensus CDS

CCDS79788.1

UniProtKB/TrEMBL

B7ZD29, Q3U2G7

Related

ENSMUSP00000122341.2, ENSMUST00000135741.8

Conserved Domains (6) summary

cd04013
Location:146 → 285

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:276 → 599

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

smart00323
Location:271 → 589

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam07106
Location:971 → 1059

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam12004
Location:589 → 1093

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:18 → 204

PH-like; Pleckstrin homology-like domain
NM_001290639.1 → NP_001277568.1 disabled homolog 2-interacting protein isoform 6

See identical proteins and their annotated locations for NP_001277568.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 2. The encoded isoform (6) is shorter at the N-terminus, compared to isoform 2. Both variants 6 and 7 encode isoform 6.

Source sequence(s)

AL929241, BC094373

Consensus CDS

CCDS71045.1

UniProtKB/TrEMBL

F6RK07

Related

ENSMUSP00000108607.2, ENSMUST00000112983.8

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
NM_001290640.1 → NP_001277569.1 disabled homolog 2-interacting protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 2.

Source sequence(s)

AK147593, AL929241, BC094373, BC118530

UniProtKB/TrEMBL

F6RK07

Related

ENSMUSP00000119058.2, ENSMUST00000124098.8

Conserved Domains (6) summary

cd04013
Location:126 → 265

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:256 → 579

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

smart00323
Location:251 → 569

RasGAP; GTPase-activator protein for Ras-like GTPases

pfam12004
Location:569 → 1073

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:44 → 184

PH-like; Pleckstrin homology-like domain

cl23720
Location:979 → 1083

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001290641.1 → NP_001277570.1 disabled homolog 2-interacting protein isoform 6

See identical proteins and their annotated locations for NP_001277570.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 2. The encoded isoform (6) is shorter at the N-terminus, compared to isoform 2. Both variants 6 and 7 encode isoform 6.

Source sequence(s)

AK147593, BC094373

Consensus CDS

CCDS71045.1

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

35448285..35621006

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162546.1 → XP_036018439.1 disabled homolog 2-interacting protein isoform X13

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:175 → 314

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:305 → 628

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:618 → 1100

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:47 → 233

PH-like; Pleckstrin homology-like domain
XM_006498305.5 → XP_006498368.1 disabled homolog 2-interacting protein isoform X11

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:175 → 314

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:305 → 628

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:618 → 1122

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:47 → 233

PH-like; Pleckstrin homology-like domain
XM_036162549.1 → XP_036018442.1 disabled homolog 2-interacting protein isoform X16

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:175 → 314

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:305 → 628

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:618 → 1100

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:47 → 233

PH-like; Pleckstrin homology-like domain
XM_006498304.5 → XP_006498367.1 disabled homolog 2-interacting protein isoform X9

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:196 → 335

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:326 → 649

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:639 → 1143

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:68 → 254

PH-like; Pleckstrin homology-like domain
XM_036162554.1 → XP_036018447.1 disabled homolog 2-interacting protein isoform X1

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_006498311.2 → XP_006498374.1 disabled homolog 2-interacting protein isoform X21

UniProtKB/TrEMBL

A2AUX3, F6RK07

Related

ENSMUSP00000108611.2, ENSMUST00000112987.8

Conserved Domains (4) summary

cd04013
Location:146 → 285

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:276 → 599

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:589 → 1093

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:18 → 204

PH-like; Pleckstrin homology-like domain
XM_036162550.1 → XP_036018443.1 disabled homolog 2-interacting protein isoform X18

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:146 → 285

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:276 → 599

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:589 → 1093

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:18 → 204

PH-like; Pleckstrin homology-like domain
XM_036162548.1 → XP_036018441.1 disabled homolog 2-interacting protein isoform X15

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:146 → 285

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:276 → 599

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:589 → 1071

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:18 → 204

PH-like; Pleckstrin homology-like domain
XM_036162552.1 → XP_036018445.1 disabled homolog 2-interacting protein isoform X20

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:146 → 285

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:276 → 599

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:589 → 1071

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:18 → 204

PH-like; Pleckstrin homology-like domain
XM_036162545.1 → XP_036018438.1 disabled homolog 2-interacting protein isoform X12

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:203 → 342

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:333 → 656

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:646 → 1150

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:75 → 261

PH-like; Pleckstrin homology-like domain
XM_036162547.1 → XP_036018440.1 disabled homolog 2-interacting protein isoform X14

UniProtKB/TrEMBL

F6RK07

Related

ENSMUSP00000108616.3, ENSMUST00000112992.9

Conserved Domains (4) summary

cd04013
Location:203 → 342

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:333 → 656

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:646 → 1099

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:75 → 261

PH-like; Pleckstrin homology-like domain
XM_017319251.3 → XP_017174740.2 disabled homolog 2-interacting protein isoform X17

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:203 → 342

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:333 → 656

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:646 → 1099

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:75 → 261

PH-like; Pleckstrin homology-like domain
XM_011239172.3 → XP_011237474.2 disabled homolog 2-interacting protein isoform X10

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:203 → 342

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:333 → 656

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:646 → 1128

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:75 → 261

PH-like; Pleckstrin homology-like domain
XM_036162539.1 → XP_036018432.1 disabled homolog 2-interacting protein isoform X1

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162541.1 → XP_036018434.1 disabled homolog 2-interacting protein isoform X3

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162542.1 → XP_036018435.1 disabled homolog 2-interacting protein isoform X4

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 975

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162544.1 → XP_036018437.1 disabled homolog 2-interacting protein isoform X7

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 975

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162540.1 → XP_036018433.1 disabled homolog 2-interacting protein isoform X2

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1004

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_030252055.2 → XP_030107915.1 disabled homolog 2-interacting protein isoform X5

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1004

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162543.1 → XP_036018436.1 disabled homolog 2-interacting protein isoform X6

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 953

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_011239175.2 → XP_011237477.1 disabled homolog 2-interacting protein isoform X8

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 953

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162556.1 → XP_036018449.1 disabled homolog 2-interacting protein isoform X7

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 975

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162553.1 → XP_036018446.1 disabled homolog 2-interacting protein isoform X1

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162551.1 → XP_036018444.1 disabled homolog 2-interacting protein isoform X19

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:138 → 277

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:268 → 591

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:581 → 1085

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:56 → 196

PH-like; Pleckstrin homology-like domain
XM_006498307.3 → XP_006498370.2 disabled homolog 2-interacting protein isoform X1

See identical proteins and their annotated locations for XP_006498370.2

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain
XM_036162555.1 → XP_036018448.1 disabled homolog 2-interacting protein isoform X1

UniProtKB/TrEMBL

F6RK07

Conserved Domains (4) summary

cd04013
Location:79 → 218

C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family

cd05136
Location:209 → 532

RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

pfam12004
Location:522 → 1026

DUF3498; Domain of unknown function (DUF3498)

cl17171
Location:1 → 137

PH-like; Pleckstrin homology-like domain