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PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 [ Homo sapiens (human) ]

Gene ID: 6992, updated on 4-Jan-2025

Summary

Official Symbol
PPP1R11provided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 11provided by HGNC
Primary source
HGNC:HGNC:9285
See related
Ensembl:ENSG00000204619 MIM:606670; AllianceGenome:HGNC:9285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255
Summary
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 46.4), thyroid (RPKM 45.6) and 25 other tissues See more
Orthologs
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Genomic context

See PPP1R11 in Genome Data Viewer
Location:
6p22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30061265..30070333)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29931133..29934607)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30034975..30038110)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene POLR1H antisense, pseudogene Neighboring gene major histocompatibility complex, class I, J (pseudogene) Neighboring gene eukaryotic translation termination factor 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30028069-30028935 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30028936-30029801 Neighboring gene RNA polymerase I subunit H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30041647-30042322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30042323-30042996 Neighboring gene ring finger protein 39 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30068196-30068705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30070193-30070692 Neighboring gene TRIM31 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:30080310-30081509 Neighboring gene tripartite motif containing 31 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
Genome-wide association study of proneness to anger.
EBI GWAS Catalog
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC125741, MGC125742, MGC125743

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm  
is_active_in nucleus  

General protein information

Preferred Names
E3 ubiquitin-protein ligase PPP1R11
Names
HCG V
hemochromatosis candidate gene V protein
inhibitor-3
protein phosphatase 1 regulatory subunit 11
protein phosphatase inhibitor 3
t-complex-associated-testis-expressed 5
NP_068778.1
XP_047275235.1
XP_047275236.1
XP_054184480.1
XP_054184481.1
XP_054185834.1
XP_054185835.1
XP_054186318.1
XP_054186319.1
XP_054186599.1
XP_054186834.1
XP_054186835.1
XP_054187095.1
XP_054187354.1
XP_054212254.1
XP_054212255.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021959.3NP_068778.1  E3 ubiquitin-protein ligase PPP1R11

    See identical proteins and their annotated locations for NP_068778.1

    Status: REVIEWED

    Source sequence(s)
    AL669914, CB126242
    Consensus CDS
    CCDS4671.1
    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1
    Related
    ENSP00000365963.3, ENST00000376772.8
    Conserved Domains (1) summary
    pfam07491
    Location:2971
    PPI_Ypi1; Protein phosphatase inhibitor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30061265..30070333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419279.1XP_047275235.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1
  2. XM_047419280.1XP_047275236.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1324951..1328425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328506.1XP_054184481.1  E3 ubiquitin-protein ligase PPP1R11 isoform X2

  2. XM_054328505.1XP_054184480.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1546630..1550104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329860.1XP_054185835.1  E3 ubiquitin-protein ligase PPP1R11 isoform X3

  2. XM_054329859.1XP_054185834.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1322775..1326249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330344.1XP_054186319.1  E3 ubiquitin-protein ligase PPP1R11 isoform X4

  2. XM_054330343.1XP_054186318.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1327875..1331083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330624.1XP_054186599.1  E3 ubiquitin-protein ligase PPP1R11 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    1410949..1414423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330860.1XP_054186835.1  E3 ubiquitin-protein ligase PPP1R11 isoform X6

  2. XM_054330859.1XP_054186834.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1322018..1325493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331120.1XP_054187095.1  E3 ubiquitin-protein ligase PPP1R11 isoform X7

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    1365778..1369252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331379.1XP_054187354.1  E3 ubiquitin-protein ligase PPP1R11 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    29931133..29934607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356280.1XP_054212255.1  E3 ubiquitin-protein ligase PPP1R11 isoform X9

  2. XM_054356279.1XP_054212254.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1

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