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Plscr3 phospholipid scramblase 3 [ Mus musculus (house mouse) ]

Gene ID: 70310, updated on 7-May-2024

Summary

Official Symbol
Plscr3provided by MGI
Official Full Name
phospholipid scramblase 3provided by MGI
Primary source
MGI:MGI:1917560
See related
Ensembl:ENSMUSG00000019461 AllianceGenome:MGI:1917560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM3; 2210403O21Rik; 2610037N06Rik
Summary
Predicted to enable several functions, including calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in apoptotic process. Acts upstream of or within cellular response to lipopolysaccharide; cholesterol homeostasis; and glucose homeostasis. Located in mitochondrion and nucleus. Is expressed in lower urinary tract; testis; and thyroid gland. Used to study obesity. Orthologous to human PLSCR3 (phospholipid scramblase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 35.8), limb E14.5 (RPKM 32.0) and 28 other tissues See more
Orthologs
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Genomic context

See Plscr3 in Genome Data Viewer
Location:
11 B3; 11 42.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69734937..69742884)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69846372..69852058)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neuroligin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69651958-69652141 Neighboring gene transmembrane protein 256 Neighboring gene tyrosine kinase, non-receptor, 1 Neighboring gene predicted gene, 32708 Neighboring gene STARR-seq mESC enhancer starr_29868 Neighboring gene transmembrane protein 95

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lead ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiolipin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid scramblase 3
Names
Ca 2+ dependent phospholipid scramblase 3
PL scramblase 3
ca(2+)-dependent phospholipid scramblase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168497.1NP_001161969.1  phospholipid scramblase 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075841, AL603707
    Consensus CDS
    CCDS24916.1
    UniProtKB/Swiss-Prot
    Q9JIZ9
    UniProtKB/TrEMBL
    Q3T9B7, Q5F283
    Related
    ENSMUSP00000104272.2, ENSMUST00000108632.8
    Conserved Domains (1) summary
    pfam03803
    Location:69285
    Scramblase
  2. NM_023564.4NP_076053.1  phospholipid scramblase 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK011716, AL603707
    Consensus CDS
    CCDS24916.1
    UniProtKB/Swiss-Prot
    Q9JIZ9
    UniProtKB/TrEMBL
    Q3T9B7, Q5F283
    Related
    ENSMUSP00000104273.3, ENSMUST00000108633.9
    Conserved Domains (1) summary
    pfam03803
    Location:69285
    Scramblase

RNA

  1. NR_033133.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK029154, CJ166750

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69734937..69742884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156975.1XP_036012868.1  phospholipid scramblase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9JIZ9
    UniProtKB/TrEMBL
    Q3T9B7, Q5F283
    Conserved Domains (1) summary
    pfam03803
    Location:69285
    Scramblase
  2. XM_006534156.3XP_006534219.1  phospholipid scramblase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9JIZ9
    UniProtKB/TrEMBL
    Q3T9B7, Q5F283
    Related
    ENSMUSP00000019605.3, ENSMUST00000019605.4
    Conserved Domains (1) summary
    pfam03803
    Location:69285
    Scramblase

RNA

  1. XR_004937019.1 RNA Sequence