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Atad2 ATPase family, AAA domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70472, updated on 11-Apr-2024

Summary

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Official Symbol
Atad2provided by MGI
Official Full Name
ATPase family, AAA domain containing 2provided by MGI
Primary source
MGI:MGI:1917722
See related
Ensembl:ENSMUSG00000022360 AllianceGenome:MGI:1917722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610509G12Rik
Summary
Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; gonad; spleen; and uterus. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 11.8), CNS E11.5 (RPKM 11.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Atad2 in Genome Data Viewer
Location:
15 D1; 15 24.32 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57957440..57998516, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58094044..58135525, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22299 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene STARR-positive B cell enhancer ABC_E941 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57966689-57966916 Neighboring gene STARR-positive B cell enhancer ABC_E3140 Neighboring gene predicted gene, 23475 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene predicted gene, 22488

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway. Li N, et al. Am J Physiol Cell Physiol, 2020 Jul 1. PMID 31747529
  2. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Duan Z, et al. Prostate, 2013 Apr. PMID 23038103
  3. Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers. Caron C, et al. Oncogene, 2010 Sep 16. PMID 20581866
  4. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors. Tong Y, et al. Biochem Biophys Res Commun, 2022 Feb 26. PMID 35085891
  5. ATAD2 controls chromatin-bound HIRA turnover. Wang T, et al. Life Sci Alliance, 2021 Dec. PMID 34580178, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATAD2 controls chromatin-bound HIRA turnover.
    Title: ATAD2 controls chromatin-bound HIRA turnover.
  2. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
    Title: ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
  3. Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
    Title: Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
  4. Results found that ATAD2 is highly expressed in hepatocellular carcinoma tissues and could affect the expression of hedghog pathway.
    Title: Epigenetic high regulation of ATAD2 regulates the Hh pathway in human hepatocellular carcinoma.
  5. EZH2 and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development.
    Title: Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38189

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATPase family AAA domain-containing protein 2
NP_001391691.1
NP_001391693.1
NP_001391694.1
NP_001391695.1
NP_081711.2
XP_036015476.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404762.1 → NP_001391691.1  ATPase family AAA domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113292

  2. NM_001404764.1 → NP_001391693.1  ATPase family AAA domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113292

  3. NM_001404765.1 → NP_001391694.1  ATPase family AAA domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113292
    UniProtKB/Swiss-Prot
    Q3UYW6, Q8CDM1
    Related
    ENSMUSP00000153936.2, ENSMUST00000228783.2

  4. NM_001404766.1 → NP_001391695.1  ATPase family AAA domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113292

  5. NM_027435.3 → NP_081711.2  ATPase family AAA domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081711.2

    Status: VALIDATED

    Source sequence(s)
    AC113292
    Consensus CDS
    CCDS37079.1
    UniProtKB/TrEMBL
    G3X963
    Related
    ENSMUSP00000043691.4, ENSMUST00000038194.5
    Conserved Domains (3) summary
    cd05528
    Location:960 → 1070
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:438 → 579
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:443 → 577
    AAA; ATPase family associated with various cellular activities (AAA)

RNA

  1. NR_175863.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113292

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    57957440..57998516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159583.1 → XP_036015476.1  ATPase family AAA domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd05528
    Location:459 → 569
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:3 → 406
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    TIGR01243
    Location:3 → 172
    CDC48; AAA family ATPase, CDC48 subfamily
    cl38936
    Location:1 → 74
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153199.1: Suppressed sequence

    Description
    NM_153199.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDM1.1 GenPept UniProtKB/Swiss-Prot:Q8CDM1

Gene LinkOut

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