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Cpm carboxypeptidase M [ Mus musculus (house mouse) ]

Gene ID: 70574, updated on 12-May-2024

Summary

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Official Symbol
Cpmprovided by MGI
Official Full Name
carboxypeptidase Mprovided by MGI
Primary source
MGI:MGI:1917824
See related
Ensembl:ENSMUSG00000020183 AllianceGenome:MGI:1917824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110060I01Rik; 5730456K23Rik; E030045M14Rik
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo endoderm; genital tubercle; limb long bone; and sensory organ. Orthologous to human CPM (carboxypeptidase M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 24.8), kidney adult (RPKM 7.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Cpm in Genome Data Viewer
Location:
10 D2; 10 66.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117465405..117523257)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117629500..117687352)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32319 Neighboring gene predicted gene, 32365 Neighboring gene STARR-positive B cell enhancer mm9_chr10:117066381-117066682 Neighboring gene STARR-positive B cell enhancer ABC_E580 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117089250-117089433 Neighboring gene STARR-positive B cell enhancer ABC_E9133 Neighboring gene STARR-positive B cell enhancer ABC_E8368 Neighboring gene predicted gene, 25709 Neighboring gene STARR-positive B cell enhancer ABC_E8369 Neighboring gene STARR-positive B cell enhancer ABC_E8869 Neighboring gene transformed mouse 3T3 cell double minute 2 Neighboring gene STARR-seq mESC enhancer starr_27991 Neighboring gene STARR-seq mESC enhancer starr_27993 Neighboring gene STARR-seq mESC enhancer starr_27994 Neighboring gene STARR-seq mESC enhancer starr_27995 Neighboring gene predicted gene, 53636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE. Sun X, et al. Biol Chem, 2008 Dec. PMID 18844448
  2. Multiple RNAs from the mouse carboxypeptidase M locus: functional RNAs or transcription noise? Guimarães AO, et al. BMC Mol Biol, 2009 Feb 8. PMID 19200403, Free PMC Article
  3. Developmental and sexual dimorphic atlas of the prenatal mouse external genitalia at the single-cell level. Amato CM, et al. Proc Natl Acad Sci U S A, 2021 Jun 22. PMID 34155146, Free PMC Article
  4. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Mould A, et al. Genes Dev, 2012 Sep 15. PMID 22987638, Free PMC Article
  5. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki S, et al. BMC Dev Biol, 2011 Mar 1. PMID 21362171, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118152

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxypeptidase M
NP_081744.1
XP_006514153.1
XP_036011899.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027468.1 → NP_081744.1  carboxypeptidase M precursor

    See identical proteins and their annotated locations for NP_081744.1

    Status: VALIDATED

    Source sequence(s)
    AC132139
    Consensus CDS
    CCDS48696.1
    UniProtKB/Swiss-Prot
    Q497S5, Q80V42, Q9CYH8
    Related
    ENSMUSP00000020399.6, ENSMUST00000020399.6
    Conserved Domains (2) summary
    cd11308
    Location:314 → 394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd03866
    Location:22 → 310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    117465405..117523257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156006.1 → XP_036011899.1  carboxypeptidase M isoform X1

    UniProtKB/Swiss-Prot
    Q497S5, Q80V42, Q9CYH8
    Conserved Domains (2) summary
    cd11308
    Location:314 → 394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd03866
    Location:22 → 310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup

  2. XM_006514090.4 → XP_006514153.1  carboxypeptidase M isoform X2

    Conserved Domains (2) summary
    cd11308
    Location:193 → 273
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:1 → 189
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80V42.2 GenPept UniProtKB/Swiss-Prot:Q80V42

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