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THY1 Thy-1 cell surface antigen [ Homo sapiens (human) ]

Gene ID: 7070, updated on 4-Jan-2025

Summary

Official Symbol
THY1provided by HGNC
Official Full Name
Thy-1 cell surface antigenprovided by HGNC
Primary source
HGNC:HGNC:11801
See related
Ensembl:ENSG00000154096 MIM:188230; AllianceGenome:HGNC:11801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD90; CDw90
Summary
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues See more
Orthologs
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Genomic context

See THY1 in Genome Data Viewer
Location:
11q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119415476..119424985, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119437019..119446528, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119286186..119295695, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:119228534-119229733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3980 Neighboring gene HNF4 motif-containing MPRA enhancer 223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119243670-119244170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119247037-119247615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119247932-119248520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119251478-119252467 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene USP2 antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 14B pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119290361-119290928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119292628-119293194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119293195-119293760 Neighboring gene double homeobox A pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119344129-119344629 Neighboring gene Sharpr-MPRA regulatory region 12960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119347323-119347824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119347825-119348324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119368781-119369640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3981 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:119381879-119382068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119404367-119404896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119417323-119418037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119430656-119431156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119431157-119431657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5631 Neighboring gene uncharacterized LOC124902770 Neighboring gene uncharacterized LOC107984398

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV Gag proteins adopt a ring-like supramolecular organization at sites of intercellular contacts and co-localize with CD63 tetraspanin and raft components GM1, Thy-1, and CD59 PubMed
gag The Matrix protein of HIV-1 Gag co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process PubMed
matrix gag HIV-1 Matrix co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ33325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GPI anchor binding  
enables GTPase activator activity  
enables GTPase activator activity  
enables integrin binding PubMed 
enables integrin binding PubMed 
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway  
involved_in angiogenesis  
involved_in cell-cell adhesion  
involved_in cell-cell signaling PubMed 
involved_in cytoskeleton organization  
involved_in focal adhesion assembly  
involved_in heterotypic cell-cell adhesion PubMed 
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway PubMed 
involved_in negative regulation of T cell receptor signaling pathway  
involved_in negative regulation of axonogenesis  
involved_in negative regulation of cell migration  
involved_in negative regulation of neuron projection regeneration PubMed 
involved_in negative regulation of protein kinase activity  
involved_in positive regulation of GTPase activity  
involved_in positive regulation of T cell activation  
involved_in positive regulation of cellular extravasation PubMed 
involved_in positive regulation of focal adhesion assembly  
involved_in positive regulation of focal adhesion assembly PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in receptor clustering  
involved_in regulation of Rho-dependent protein serine/threonine kinase activity PubMed 
involved_in regulation of cell-matrix adhesion PubMed 
involved_in retinal cone cell development  
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in axolemma  
located_in cell surface PubMed 
is_active_in dendrite  
located_in dendrite membrane  
located_in endoplasmic reticulum  
is_active_in external side of plasma membrane  
located_in external side of plasma membrane  
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in focal adhesion PubMed 
located_in glutamatergic synapse  
located_in growth cone  
is_active_in membrane raft  
located_in membrane raft PubMed 
located_in neuronal cell body membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse  
located_in presynapse  

General protein information

Preferred Names
thy-1 membrane glycoprotein
Names
Thy-1 T-cell antigen
thy-1 antigen
NP_001298089.1
NP_001298091.1
NP_001358979.1
NP_006279.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311160.2NP_001298089.1  thy-1 membrane glycoprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001298089.1

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8424.1
    UniProtKB/Swiss-Prot
    P04216, Q16008, Q9NSP1
    UniProtKB/TrEMBL
    B0YJA4, E9PIM6
    Related
    ENSP00000431301.1, ENST00000528522.5
    Conserved Domains (1) summary
    pfam00047
    Location:21117
    ig; Immunoglobulin domain
  2. NM_001311162.2NP_001298091.1  thy-1 membrane glycoprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001298091.1

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8424.1
    UniProtKB/Swiss-Prot
    P04216, Q16008, Q9NSP1
    UniProtKB/TrEMBL
    B0YJA4, E9PIM6
    Related
    ENSP00000435753.1, ENST00000524659.1
    Conserved Domains (1) summary
    pfam00047
    Location:21117
    ig; Immunoglobulin domain
  3. NM_001372050.1NP_001358979.1  thy-1 membrane glycoprotein isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS91612.1
    UniProtKB/TrEMBL
    E9PIM6, J3QRJ3
    Related
    ENSP00000464248.1, ENST00000580275.5
    Conserved Domains (1) summary
    pfam00047
    Location:9100
    ig; Immunoglobulin domain
  4. NM_006288.5NP_006279.2  thy-1 membrane glycoprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006279.2

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8424.1
    UniProtKB/Swiss-Prot
    P04216, Q16008, Q9NSP1
    UniProtKB/TrEMBL
    B0YJA4, E9PIM6
    Related
    ENSP00000284240.6, ENST00000284240.10
    Conserved Domains (1) summary
    pfam00047
    Location:21117
    ig; Immunoglobulin domain

RNA

  1. NR_164077.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003396

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    119415476..119424985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    119437019..119446528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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