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Arrdc2 arrestin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70807, updated on 30-Apr-2024

Summary

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Official Symbol
Arrdc2provided by MGI
Official Full Name
arrestin domain containing 2provided by MGI
Primary source
MGI:MGI:1918057
See related
Ensembl:ENSMUSG00000002910 AllianceGenome:MGI:1918057
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ilad1; 4632416I05Rik
Summary
Predicted to be involved in protein transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and plasma membrane. Is expressed in metanephros and testis. Orthologous to human ARRDC2 (arrestin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 30.6), ovary adult (RPKM 22.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arrdc2 in Genome Data Viewer
Location:
8 B3.3; 8 34.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71287773..71293173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70835129..70839720, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene microRNA 7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73330531-73330714 Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene coiled-coil domain containing 124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins. Nichols CD, et al. J Neurochem, 2004 Aug. PMID 15255935
  2. The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. Patwari P, et al. J Biol Chem, 2006 Aug 4. PMID 16766796, Free PMC Article
  3. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nott A, et al. Nat Neurosci, 2016 Nov. PMID 27428650, Free PMC Article
  4. Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Wu Y, et al. Front Cell Dev Biol, 2020. PMID 33634103, Free PMC Article
  5. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arrestin domain-containing protein 2
Names
induced by lysergic acid diethylamide-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027560.1 → NP_081836.1  arrestin domain-containing protein 2

    See identical proteins and their annotated locations for NP_081836.1

    Status: PROVISIONAL

    Source sequence(s)
    AK014582
    Consensus CDS
    CCDS40376.1
    UniProtKB/Swiss-Prot
    Q3UVK8, Q3UXC6, Q9D668
    UniProtKB/TrEMBL
    Q0GJK2
    Related
    ENSMUSP00000002989.10, ENSMUST00000002989.11
    Conserved Domains (2) summary
    smart01017
    Location:180 → 307
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:9 → 158
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71287773..71293173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154287.1 → XP_036010180.1  arrestin domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    smart01017
    Location:28 → 155
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain

  2. XM_017312963.3 → XP_017168452.1  arrestin domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    smart01017
    Location:28 → 155
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain

RNA

  1. XR_379046.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D668.1 GenPept UniProtKB/Swiss-Prot:Q9D668

Gene LinkOut

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