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Ppp6r2 protein phosphatase 6, regulatory subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 71474, updated on 30-Apr-2024

Summary

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Official Symbol
Ppp6r2provided by MGI
Official Full Name
protein phosphatase 6, regulatory subunit 2provided by MGI
Primary source
MGI:MGI:1918724
See related
Ensembl:ENSMUSG00000036561 AllianceGenome:MGI:1918724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp6r2; Saps2; 1110033O10Rik; 8430411H09Rik; B230107H12Rik
Summary
Predicted to enable protein phosphatase binding activity and protein phosphatase regulator activity. Predicted to be involved in regulation of phosphoprotein phosphatase activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human PPP6R2 (protein phosphatase 6 regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 17.5), adrenal adult (RPKM 14.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 44.76 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89095654..89171218)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89211451..89287015)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene plexin B2 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene DENN domain containing 6B Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene SET binding factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:89140718-89140905 Neighboring gene STARR-positive B cell enhancer ABC_E5509 Neighboring gene microRNA 6959 Neighboring gene adrenomedullin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson B, et al. J Biol Chem, 2006 Aug 11. PMID 16769727
  2. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. Hedlund E, et al. J Neurosci Res, 2004 Feb 1. PMID 14743444
  3. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 2
Names
SAPS domain family, member 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356969.1 → NP_001343898.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC160538
    Consensus CDS
    CCDS27743.1
    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    UniProtKB/TrEMBL
    G3X9K4
    Related
    ENSMUSP00000154087.2, ENSMUST00000228284.2
    Conserved Domains (2) summary
    PHA03247
    Location:666 → 922
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 534
    SAPS; SIT4 phosphatase-associated protein

  2. NM_001356970.1 → NP_001343899.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC160538
    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:526 → 782
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 394
    SAPS; SIT4 phosphatase-associated protein

  3. NM_026813.2 → NP_081089.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_081089.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest variant and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC160538
    Consensus CDS
    CCDS27743.1
    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    UniProtKB/TrEMBL
    G3X9K4
    Conserved Domains (2) summary
    PHA03247
    Location:666 → 922
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 534
    SAPS; SIT4 phosphatase-associated protein

  4. NM_027805.2 → NP_082081.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_082081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK084684
    UniProtKB/TrEMBL
    Q8C3X1
    Related
    ENSMUST00000226779.2
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 207
    SAPS; SIT4 phosphatase-associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89095654..89171218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521405.3 → XP_006521468.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:694 → 950
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 562
    SAPS; SIT4 phosphatase-associated protein

  2. XM_036159591.1 → XP_036015484.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:512 → 768
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:26 → 353
    SAPS; SIT4 phosphatase-associated protein

  3. XM_006521398.3 → XP_006521461.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006521461.1

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:721 → 977
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 562
    SAPS; SIT4 phosphatase-associated protein

  4. XM_006521406.3 → XP_006521469.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    UniProtKB/TrEMBL
    A0A5F8MQ25
    Related
    ENSMUSP00000159040.2, ENSMUST00000238818.2
    Conserved Domains (2) summary
    PHA03247
    Location:693 → 949
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 534
    SAPS; SIT4 phosphatase-associated protein

  5. XM_006521403.3 → XP_006521466.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:715 → 971
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 556
    SAPS; SIT4 phosphatase-associated protein

  6. XM_030248767.2 → XP_030104627.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:688 → 944
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 556
    SAPS; SIT4 phosphatase-associated protein

  7. XM_030248768.2 → XP_030104628.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:687 → 943
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 528
    SAPS; SIT4 phosphatase-associated protein

  8. XM_017316748.2 → XP_017172237.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:581 → 837
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 422
    SAPS; SIT4 phosphatase-associated protein

  9. XM_030248772.2 → XP_030104632.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:581 → 837
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 422
    SAPS; SIT4 phosphatase-associated protein

  10. XM_036159588.1 → XP_036015481.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:559 → 815
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:1 → 400
    SAPS; SIT4 phosphatase-associated protein

  11. XM_006521404.3 → XP_006521467.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:702 → 958
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:109 → 543
    SAPS; SIT4 phosphatase-associated protein

  12. XM_006521401.3 → XP_006521464.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006521464.1

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:721 → 977
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 562
    SAPS; SIT4 phosphatase-associated protein

  13. XM_030248766.2 → XP_030104626.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    UniProtKB/TrEMBL
    A0A5F8MQ25
    Conserved Domains (2) summary
    PHA03247
    Location:693 → 949
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 534
    SAPS; SIT4 phosphatase-associated protein

  14. XM_017316749.3 → XP_017172238.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:581 → 837
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 422
    SAPS; SIT4 phosphatase-associated protein

  15. XM_036159586.1 → XP_036015479.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:674 → 930
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:109 → 515
    SAPS; SIT4 phosphatase-associated protein

  16. XM_036159587.1 → XP_036015480.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:647 → 903
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:109 → 515
    SAPS; SIT4 phosphatase-associated protein

  17. XM_006521400.3 → XP_006521463.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006521463.1

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:721 → 977
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 562
    SAPS; SIT4 phosphatase-associated protein

  18. XM_030248769.2 → XP_030104629.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:675 → 931
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:109 → 543
    SAPS; SIT4 phosphatase-associated protein

  19. XM_030248773.2 → XP_030104633.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:581 → 837
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 422
    SAPS; SIT4 phosphatase-associated protein

  20. XM_006521399.3 → XP_006521462.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006521462.1

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:721 → 977
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 562
    SAPS; SIT4 phosphatase-associated protein

  21. XM_030248765.2 → XP_030104625.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    UniProtKB/TrEMBL
    A0A5F8MQ25
    Conserved Domains (2) summary
    PHA03247
    Location:693 → 949
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 534
    SAPS; SIT4 phosphatase-associated protein

  22. XM_030248774.2 → XP_030104634.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:581 → 837
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 422
    SAPS; SIT4 phosphatase-associated protein

  23. XM_030248770.2 → XP_030104630.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:660 → 916
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 528
    SAPS; SIT4 phosphatase-associated protein

  24. XM_017316750.2 → XP_017172239.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:553 → 809
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 394
    SAPS; SIT4 phosphatase-associated protein

  25. XM_030248775.2 → XP_030104635.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X15

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:554 → 810
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 422
    SAPS; SIT4 phosphatase-associated protein

  26. XM_036159589.1 → XP_036015482.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:553 → 809
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 394
    SAPS; SIT4 phosphatase-associated protein

  27. XM_030248776.2 → XP_030104636.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:526 → 782
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 394
    SAPS; SIT4 phosphatase-associated protein

  28. XM_030248779.2 → XP_030104639.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:432 → 691
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:26 → 276
    SAPS; SIT4 phosphatase-associated protein

  29. XM_030248778.2 → XP_030104638.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:526 → 782
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 394
    SAPS; SIT4 phosphatase-associated protein

  30. XM_030248777.2 → XP_030104637.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

    UniProtKB/TrEMBL
    Q6A018
    Conserved Domains (2) summary
    PHA03247
    Location:526 → 782
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:2 → 394
    SAPS; SIT4 phosphatase-associated protein

  31. XM_030248764.2 → XP_030104624.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    Conserved Domains (2) summary
    PHA03247
    Location:694 → 950
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 562
    SAPS; SIT4 phosphatase-associated protein

  32. XM_017316747.2 → XP_017172236.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

    UniProtKB/Swiss-Prot
    Q8R3Q2, Q9CXB7
    UniProtKB/TrEMBL
    G3X9K4
    Conserved Domains (2) summary
    PHA03247
    Location:666 → 922
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:128 → 534
    SAPS; SIT4 phosphatase-associated protein

  33. XM_030248780.1 → XP_030104640.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

    UniProtKB/TrEMBL
    A4FU84
    Conserved Domains (2) summary
    PHA03247
    Location:277 → 536
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:36 → 121
    SAPS; SIT4 phosphatase-associated protein

  34. XM_011245729.1 → XP_011244031.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

    UniProtKB/TrEMBL
    A4FU84
    Conserved Domains (2) summary
    PHA03247
    Location:341 → 600
    PHA03247; large tegument protein UL36; Provisional
    pfam04499
    Location:1 → 185
    SAPS; SIT4 phosphatase-associated protein

RNA

  1. XR_004938872.1 RNA Sequence

  2. XR_003951439.2 RNA Sequence

  3. XR_003951441.2 RNA Sequence

  4. XR_384046.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3Q2.1 GenPept UniProtKB/Swiss-Prot:Q8R3Q2

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