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Gtf2a1l general transcription factor IIA, 1-like [ Mus musculus (house mouse) ]

Gene ID: 71828, updated on 5-Mar-2024

Summary

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Official Symbol
Gtf2a1lprovided by MGI
Official Full Name
general transcription factor IIA, 1-likeprovided by MGI
Primary source
MGI:MGI:1919078
See related
Ensembl:ENSMUSG00000024154 AllianceGenome:MGI:1919078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alf; Gtf2a1lf; 1700011N16Rik
Summary
Predicted to enable DNA binding activity. Predicted to be involved in cognition and transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription factor TFIIA complex. Is expressed in early conceptus; gonad; and ureter. Orthologous to human GTF2A1L (general transcription factor IIA subunit 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 130.5) See more
Orthologs
human all
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Genomic context

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Location:
17 E4; 17 58.22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88972921..89022585)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (88665493..88715157)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene stonin 1 Neighboring gene predicted gene, 31704 Neighboring gene STARR-seq mESC enhancer starr_43565 Neighboring gene predicted gene, 31903 Neighboring gene predicted gene, 38460 Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene STARR-seq mESC enhancer starr_43566 Neighboring gene STARR-seq mESC enhancer starr_43567 Neighboring gene predicted gene 9407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A short core promoter drives expression of the ALF transcription factor in reproductive tissues of male and female mice. Han S, et al. Biol Reprod, 2004 Sep. PMID 15151936
  2. Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation. Xie W, et al. J Biol Chem, 2002 May 17. PMID 11889132
  3. TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Yu C, et al. Nat Commun, 2020 Dec 22. PMID 33353944, Free PMC Article
  4. Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Oyama T, et al. Dev Cell, 2013 Oct 28. PMID 24176642, Free PMC Article
  5. Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice. Xiao L, et al. Gene Expr Patterns, 2006 Apr. PMID 16412700

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
    Title: TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
  2. Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms.
    Title: Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.
  3. unique core promoter that is active in both male and female reproductive tissue suggesting ALF may have a regulatory role in male and female gametogenic gene expression programs.
    Title: A short core promoter drives expression of the ALF transcription factor in reproductive tissues of male and female mice.
  4. Endogenous ALF is proteolytically cleaved to give alpha- and beta-subunits and its cleavage site was mapped.
    Title: Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells.
  5. a role for ALF in the assembly and stabilization of initiation complexes in germ cells is likely to be similar or identical to the role of TFIIA in somatic cells.
    Title: The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TFIIA-alpha and beta-like factor
Names
TfIIa-alpha/beta-like factor
general transcription factor II A, 1-like factor
general transcription factor IIA, 1-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023630.2 → NP_076119.2  TFIIA-alpha and beta-like factor

    See identical proteins and their annotated locations for NP_076119.2

    Status: VALIDATED

    Source sequence(s)
    AK005881, BY092414
    Consensus CDS
    CCDS29024.1
    UniProtKB/Swiss-Prot
    Q8R4I4, Q99PM2, Q9DAF4
    Related
    ENSMUSP00000024970.5, ENSMUST00000024970.11
    Conserved Domains (2) summary
    cd07976
    Location:411 → 468
    TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
    pfam03153
    Location:10 → 468
    TFIIA; Transcription factor IIA, alpha/beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88972921..89022585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246628.3 → XP_011244930.1  TFIIA-alpha and beta-like factor isoform X1

    Conserved Domains (1) summary
    pfam03153
    Location:99 → 347
    TFIIA; Transcription factor IIA, alpha/beta subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4I4.2 GenPept UniProtKB/Swiss-Prot:Q8R4I4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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